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LB244

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Catalog No. T79730Cas No. 3074622-05-9

LB244, a homologue of BB-Cl-amidine, functions as an orally effective STING inhibitor with an EC50 value of 0.8 μM, applicable in the treatment of STING-dependent inflammatory diseases. However, pharmacokinetic studies have shown that LB244 exhibits limited oral activity in mice [1].

LB244

LB244

😃Good
Catalog No. T79730Cas No. 3074622-05-9
LB244, a homologue of BB-Cl-amidine, functions as an orally effective STING inhibitor with an EC50 value of 0.8 μM, applicable in the treatment of STING-dependent inflammatory diseases. However, pharmacokinetic studies have shown that LB244 exhibits limited oral activity in mice [1].
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$28735 days35 days
5 mg$1,29035 days35 days
10 mg$2,29035 days35 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
LB244, a homologue of BB-Cl-amidine, functions as an orally effective STING inhibitor with an EC50 value of 0.8 μM, applicable in the treatment of STING-dependent inflammatory diseases. However, pharmacokinetic studies have shown that LB244 exhibits limited oral activity in mice [1].
In vivo
Pharmacokinetic results in mice indicate that compound LB244, administered at 10 mg/kg orally (po) and 5 mg/kg intraperitoneally (ip), exhibits limited oral bioavailability (C max = 0.04 μM) and a short half-life (T 1/2 = 2.8 h). Its in vivo clearance rate is 2854.3 mL/min/kg [1].
Chemical Properties
Molecular Weight537.57
FormulaC30H27N5O5
Cas No.3074622-05-9
SmilesO=C(C1=CC=C(C2=CC=CC=C2)C=C1)N[C@H](C3=NC4=CC=CC=C4N3)CCCCNC(C5=CC=C([N+]([O-])=O)O5)=O
ColorWhite
AppearanceSolid
Storage & Solubility Information
Storagestore at low temperature | 02 | Shipping with blue ice/Shipping at ambient temperature.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Stock solution preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
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