Powder: -20°C for 3 years | In solvent: -80°C for 1 year
LB244, a homologue of BB-Cl-amidine, functions as an orally effective STING inhibitor with an EC50 value of 0.8 μM, applicable in the treatment of STING-dependent inflammatory diseases. However, pharmacokinetic studies have shown that LB244 exhibits limited oral activity in mice [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | 35 days | $ 198.00 | |
5 mg | 35 days | $ 890.00 | |
10 mg | 35 days | $ 1,580.00 |
Description | LB244, a homologue of BB-Cl-amidine, functions as an orally effective STING inhibitor with an EC50 value of 0.8 μM, applicable in the treatment of STING-dependent inflammatory diseases. However, pharmacokinetic studies have shown that LB244 exhibits limited oral activity in mice [1]. |
In vivo | Pharmacokinetic results in mice indicate that compound LB244, administered at 10 mg/kg orally (po) and 5 mg/kg intraperitoneally (ip), exhibits limited oral bioavailability (C max = 0.04 μM) and a short half-life (T 1/2 = 2.8 h). Its in vivo clearance rate is 2854.3 mL/min/kg [1]. |
Molecular Weight | 537.57 |
Formula | C30H27N5O5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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LB244 Immunology/Inflammation STING inhibitor inhibit