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LB244

Name: LB244
Brand: TargetMol
SKU: T79730
Rating: 4.5 (1 reviews)

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Catalog No. T79730Cas No. 3074622-05-9

Alias LB-244, LB 244

LB244 is a homologue of BB-Cl-amidine and functions as an orally effective STING inhibitor with an EC50 value of 0.8 μM, capable of suppressing STING-dependent inflammatory signaling, although pharmacokinetic studies indicate limited oral activity in mice, making it a useful tool for mechanistic investigations of innate immunity and inflammatory disease models.

LB244

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Catalog No. T79730Alias LB-244, LB 244Cas No. 3074622-05-9

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$287	35 days	35 days
5 mg	$1,290	35 days	35 days
10 mg	$2,290	35 days	35 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Solid

Color:White

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Product Introduction

Bioactivity

Description	LB244 is a homologue of BB-Cl-amidine and functions as an orally effective STING inhibitor with an EC50 value of 0.8 μM, capable of suppressing STING-dependent inflammatory signaling, although pharmacokinetic studies indicate limited oral activity in mice, making it a useful tool for mechanistic investigations of innate immunity and inflammatory disease models.
Targets&IC50	STING:0.8 - 4.5 μM
In vitro	In cellular assays using human THP-1 monocytes and murine macrophages, the cells were stimulated with the cyclic dinucleotide agonist 2'3'-cGAMP to activate the pathway. LB244 was applied at concentrations corresponding to an IC50 range of 0.8 to 4.5 μM [1].
In vivo	Pharmacokinetic profiling was conducted in mice to evaluate the systemic properties of the compound. LB244 was administered via oral gavage (10 mg/kg) or intraperitoneal injection (5 mg/kg). Blood samples were analyzed to determine metabolic parameters, revealing a systemic clearance of 2854.3 mL/min/kg and a half-life (T1/2) of 2.8 hours. Following oral administration, the plasma analysis detected a maximal concentration (Cmax) of 0.04 uM [1].
Synonyms	LB-244, LB 244

Chemical Properties

Molecular Weight	537.57
Formula	C₃₀H₂₇N₅O₅
Cas No.	3074622-05-9
Smiles	O=C(C1=CC=C(C2=CC=CC=C2)C=C1)N[C@H](C3=NC4=CC=CC=C4N3)CCCCNC(C5=CC=C([N+]([O-])=O)O5)=O

Storage & Solubility Information

Storage

store at low temperature | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (148.82 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8602 mL	9.3011 mL	18.6022 mL	93.0111 mL
5 mM	0.3720 mL	1.8602 mL	3.7204 mL	18.6022 mL
10 mM	0.1860 mL	0.9301 mL	1.8602 mL	9.3011 mL
20 mM	0.0930 mL	0.4651 mL	0.9301 mL	4.6506 mL
50 mM	0.0372 mL	0.1860 mL	0.3720 mL	1.8602 mL
100 mM	0.0186 mL	0.0930 mL	0.1860 mL	0.9301 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

LB244

LB244

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