Powder: -20°C for 3 years | In solvent: -80°C for 1 year
JNJ-1013 is a potent and selective IRAK1 degrader, demonstrating IC50 values of 72 nM for IRAK1, 443 nM for IRAK4, and 1071 nM for VHL FP. It induces apoptosis and augments the expression of cleaved PARP while decreasing the expression of IRAK1, p-IKBα, and pSTAT3(Tyr705) [1].
Pack Size | Availability | Price/USD | Quantity |
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5 mg | 35 days | $ 673.00 |
Description | JNJ-1013 is a potent and selective IRAK1 degrader, demonstrating IC50 values of 72 nM for IRAK1, 443 nM for IRAK4, and 1071 nM for VHL FP. It induces apoptosis and augments the expression of cleaved PARP while decreasing the expression of IRAK1, p-IKBα, and pSTAT3(Tyr705) [1]. |
Targets&IC50 | IRAK1:72 nM, IRAK4:443 nM, VHL FP:1071 nM |
In vitro | JNJ-1013 (Degrader-3; 1.5-10000 nM; 24 hours) degrades IRAK1 protein in a dose-dependent manner with a DC50 value of 3 nM [1]. At 1 µM, JNJ-1013 diminishes the expression of IRAK1 induced by MG-132 in a dose-dependent fashion [1]. Furthermore, JNJ-1013 (0.01, 0.03, 0.1, 0.3, 1 µM; 24 h) reduces the expression of IRAK1, p-IKBα, pSTAT3(Tyr705), and increases the expression of cleaved PARP [1]. |
Molecular Weight | 878.05 |
Formula | C46H55N9O7S |
CAS No. | 2597343-08-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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JNJ-1013 2597343-08-1 Apoptosis inhibitor inhibit