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JNJ-1013 (Alias: JNJ1013)

Name: JNJ-1013
Brand: TargetMol
SKU: T78054
Price: 88 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T78054 Copy Product Info

Purity: 99.59%

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JNJ-1013 is a potent and selective IRAK1 degrader, with IC50 values of 72 nM for IRAK1, 443 nM for IRAK4, and 1071 nM for VHL FP. It induces apoptosis, increases cleaved PARP expression, and decreases the expression of IRAK1, p-IKBα, and pSTAT3(Tyr705) [1].

JNJ-1013

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Catalog No. T78054

Alias JNJ1013

Cas No. 2597343-08-1

Pack Size	Price	USA Stock	Global Stock	Quantity
1 mg	$88	-	In Stock

In stock · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.59%

Appearance:Solid

Color:Yellow

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COA LCMS

Product Introduction

Bioactivity

Description	JNJ-1013 is a potent and selective IRAK1 degrader, with IC50 values of 72 nM for IRAK1, 443 nM for IRAK4, and 1071 nM for VHL FP. It induces apoptosis, increases cleaved PARP expression, and decreases the expression of IRAK1, p-IKBα, and pSTAT3(Tyr705) [1].
Targets&IC50	IRAK1:72 nM, VHL FP:1071 nM, IRAK4:443 nM
In vitro	JNJ-1013 (Degrader-3; 1.5-10000 nM; 24 hours) degrades IRAK1 protein in a dose-dependent manner with a DC50 value of 3 nM [1]. At 1 µM, JNJ-1013 diminishes the expression of IRAK1 induced by MG-132 in a dose-dependent fashion [1]. Additionally, JNJ-1013 (0.01, 0.03, 0.1, 0.3, 1 µM; 24 h) reduces the expression of IRAK1, p-IKBα, pSTAT3(Tyr705), and increases the expression of cleaved PARP [1].
Synonyms	JNJ1013

Chemical Properties

Molecular Weight	878.05
Formula	C₄₆H₅₅N₉O₇S
Cas No.	2597343-08-1
Smiles	C([C@@H](NC(COC1CCN(CC1)C2=CC(OC)=C(NC(=O)C=3N=C(C=CC3)C=4C=CNN4)C=C2)=O)C(C)(C)C)(=O)N5[C@H](C(N[C@@H](C)C6=CC=C(C=C6)C=7SC=NC7C)=O)C[C@@H](O)C5

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 20 mg/mL (22.78 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.1389 mL	5.6944 mL	11.3889 mL	56.9444 mL
5 mM	0.2278 mL	1.1389 mL	2.2778 mL	11.3889 mL
10 mM	0.1139 mL	0.5694 mL	1.1389 mL	5.6944 mL
20 mM	0.0569 mL	0.2847 mL	0.5694 mL	2.8472 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc