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Rhamnazin
🥰Excellent
Catalog No. TN2150Cas No. 552-54-5
Alias 3',7-Dimethylquercetin
Rhamnazin (3',7-Dimethylquercetin) is an orally active VEGFR2 signaling inhibitor with anti-angiogenesis, anti-tumor, antioxidant, and anti-inflammatory activities. It inhibits VEGFR2 kinase and is used for leukemia research.
Rhamnazin
🥰Excellent
Catalog No. TN2150Alias 3',7-DimethylquercetinCas No. 552-54-5
Rhamnazin (3',7-Dimethylquercetin) is an orally active VEGFR2 signaling inhibitor with anti-angiogenesis, anti-tumor, antioxidant, and anti-inflammatory activities. It inhibits VEGFR2 kinase and is used for leukemia research.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $279 | In Stock | |
| 5 mg | $838 | In Stock | |
| 10 mg | $1,130 | In Stock | |
| 25 mg | $1,680 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $849 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Rhamnazin (3',7-Dimethylquercetin) is an orally active VEGFR2 signaling inhibitor with anti-angiogenesis, anti-tumor, antioxidant, and anti-inflammatory activities. It inhibits VEGFR2 kinase and is used for leukemia research. |
| Targets&IC50 | VEGFR2:4.68 μM |
| In vitro | Rhamnazin (5, 10, and 15 µM, 24h) reduces the proliferation and invasion of hepatocellular carcinoma (HCC) cells. [2] Rhamnazin directly inhibited VEGFR2 kinase activity in a dose-dependent manner with an IC50 of 4.68 μM. [3] |
| In vivo | Treatment with Rhamnazin (10-30 mg/kg) significantly improved experimental brain injury in rats, with results showing significant reduction of edema and improved grip strength. [1] Rhamnazin (200 mg/kg/ day orally) significantly inhibited the growth of human tumor xenografts and reduced the microvascular density (MVD) of tumor sections. [3] |
| Synonyms | 3',7-Dimethylquercetin |
| Molecular Weight | 330.29 |
| Formula | C17H14O7 |
| Cas No. | 552-54-5 |
| Smiles | O=C1C(O)=C(OC2=CC(OC)=CC(O)=C12)C=3C=CC(O)=C(OC)C3 |
| Relative Density. | 1.507 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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