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Microcystin-LR
🥰Excellent
Catalog No. T5204Cas No. 101043-37-2
Alias Toxin T 17 (Microcystis aeruginosa), Microcystin-LR, Microcystis aeruginosa, MC-LR, Cyanoginosin-LR
Microcystin-LR (Cyanoginosin-LR) is a potent inhibitor of type 1 and type 2A protein phosphatases (PP1 and PP2A), with IC50s of 1.7 nM and 0.04 nM, respectively.
Microcystin-LR
🥰Excellent
Catalog No. T5204Alias Toxin T 17 (Microcystis aeruginosa), Microcystin-LR, Microcystis aeruginosa, MC-LR, Cyanoginosin-LRCas No. 101043-37-2
Microcystin-LR (Cyanoginosin-LR) is a potent inhibitor of type 1 and type 2A protein phosphatases (PP1 and PP2A), with IC50s of 1.7 nM and 0.04 nM, respectively.
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Product Introduction
Bioactivity
Chemical Properties
| Description | Microcystin-LR (Cyanoginosin-LR) is a potent inhibitor of type 1 and type 2A protein phosphatases (PP1 and PP2A), with IC50s of 1.7 nM and 0.04 nM, respectively. |
| Targets&IC50 | PP1:1.7 nM, PP2A:0.04 nM |
| In vitro | Microcystins, toxic compounds generated during cyanobacterial blooms related to water eutrophication[2], demonstrate significant inhibition of both type 1 (IC50=1.7 nM) and type 2A (IC50=0.04 nM) protein phosphatases, exceeding the inhibitory efficacy of okadaic acid by more than tenfold under identical conditions. Remarkably, microcystin-LR completely inhibits type 2A protein phosphatases in diluted mammalian cell extracts at a concentration of 0.5 nM, whereas type 1 phosphatases exhibit minimal inhibition at the same concentration[1]. |
| Alias | Toxin T 17 (Microcystis aeruginosa), Microcystin-LR, Microcystis aeruginosa, MC-LR, Cyanoginosin-LR |
| Molecular Weight | 995.17 |
| Formula | C49H74N10O12 |
| Cas No. | 101043-37-2 |
| Smiles | CC(C)C[C@@H](C(N[C@H]([C@H](C)C(N[C@@H](CCCNC(N)=N)C(N([C@@H](CCC(N(C)C(C(N[C@@H]1C)=O)=C)=O)C(O)=O)C(C(C)[C@H](/C=C/C(/C)=C/[C@H](C)[C@H](Cc2ccccc2)OC)N)=O)=O)=O)C(O)=O)=O)NC1=O |
| Relative Density. | 1.29g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | Ethanol: 0.5 mg/mL (0.50 mM), Sonication is recommended. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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