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[6]-Gingerol

Name: [6]-Gingerol
Brand: TargetMol
SKU: T3405
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3405Cas No. 23513-14-6

Alias gingerol, 6-Gingerol, (S)-(+)-[6]Gingerol

[6]-Gingerol ((S)-(+)-[6]Gingerol), an antioxidant, protects HL-60 cells from oxidative stress. It has protective effects for Yous tumors in the pancreas, ovaries, breast tissue, the bowel, among other tissues.

[6]-Gingerol

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Purity: 99.95%

Catalog No. T3405Alias gingerol, 6-Gingerol, (S)-(+)-[6]GingerolCas No. 23513-14-6

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$35	In Stock	In Stock
10 mg	$50	In Stock	In Stock
25 mg	$81	In Stock	In Stock
50 mg	$119	In Stock	In Stock
100 mg	$175	In Stock	In Stock
200 mg	$258	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$34	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.95%

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	[6]-Gingerol ((S)-(+)-[6]Gingerol), an antioxidant, protects HL-60 cells from oxidative stress. It has protective effects for Yous tumors in the pancreas, ovaries, breast tissue, the bowel, among other tissues.
In vitro	[6]-Gingerol selectively inhibits proliferation and induces apoptosis in colon cancer cells while sparing normal colon cells. It modulates cell signaling by down-regulating phorbol myristate acetate-induced phosphorylation of ERK1/2 and JNK MAP kinases and reducing AP-1 transcription factor activation, with minimal impact on p38 MAP kinase phosphorylation and NF-kappa B activation[1]. Moreover, [6]-gingerol enhances intestinal barrier function and diminishes proinflammatory responses in DSS-treated Caco-2 monolayers, partly by activating AMPK[2]. Additionally, it significantly reduces osteosarcoma cell viability in a dose-dependent manner, increases sub-G1 cell cycle arrest, and activates caspase cascades while adjusting Bcl2 and Bax protein levels[3].
In vivo	In animal studies, [6]-gingerol effectively mitigates DSS-induced colitis symptoms by reversing body weight loss, decreasing intestinal bleeding, and preventing colon shortening. It also inhibits the DSS-induced increase in proinflammatory cytokines (IL-1β, TNFα, and IL-12)[2].
Cell Research	[6]-gingerol stock (20 mg/mL) is prepared in ethanol and the working concentrations are prepared by diluting this stock in dimethyl sufoxide (DMSO). For MTT assay, 5×103 cells/well of human colon cancer cells and 104 cells/well of mouse IECs are seeded in 96-well plates. Cells are treated with [6]-gingerol for 48 h,72 h or 96 h before performing MTT assay and for 16 h before Annexin-V staining[1].
Synonyms	gingerol, 6-Gingerol, (S)-(+)-[6]Gingerol

Chemical Properties

Molecular Weight	294.39
Formula	C₁₇H₂₆O₄
Cas No.	23513-14-6
Smiles	CCCCC[C@H](O)CC(=O)CCc1ccc(O)c(OC)c1
Relative Density.	1.083 g/cm3

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight,keep away from moisture | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.: Soluble

DMSO: 50 mg/mL (169.84 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.79 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3969 mL	16.9843 mL	33.9685 mL	169.8427 mL
5 mM	0.6794 mL	3.3969 mL	6.7937 mL	33.9685 mL
10 mM	0.3397 mL	1.6984 mL	3.3969 mL	16.9843 mL
20 mM	0.1698 mL	0.8492 mL	1.6984 mL	8.4921 mL
50 mM	0.0679 mL	0.3397 mL	0.6794 mL	3.3969 mL
100 mM	0.0340 mL	0.1698 mL	0.3397 mL	1.6984 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc