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Didesmethylrocaglamide

Name: Didesmethylrocaglamide
Brand: TargetMol
SKU: T36750
Rating: 4.5 (1 reviews)

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Catalog No. T36750Cas No. 177262-30-5

Didesmethylrocaglamide, a Rocaglamide derivative, is a potent eukaryotic initiation factor 4A (eIF4A) inhibitor that exhibits strong growth-inhibitory effects, with an IC50 of 5 nM. It hinders several growth-promoting signaling pathways and triggers apoptosis in tumor cells, demonstrating antitumor activity[1].

Didesmethylrocaglamide

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Catalog No. T36750Cas No. 177262-30-5

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$1,520	10-14 weeks	10-14 weeks
50 mg	$1,980	10-14 weeks	10-14 weeks
100 mg	$2,500	10-14 weeks	10-14 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

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Product Introduction

Bioactivity

Description

Chemical Properties

Molecular Weight	477.51
Formula	C₂₇H₂₇NO₇
Cas No.	177262-30-5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (209.42 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0942 mL	10.4710 mL	20.9420 mL	104.7098 mL
5 mM	0.4188 mL	2.0942 mL	4.1884 mL	20.9420 mL
10 mM	0.2094 mL	1.0471 mL	2.0942 mL	10.4710 mL
20 mM	0.1047 mL	0.5235 mL	1.0471 mL	5.2355 mL
50 mM	0.0419 mL	0.2094 mL	0.4188 mL	2.0942 mL
100 mM	0.0209 mL	0.1047 mL	0.2094 mL	1.0471 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc