Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CIAC001, a pyruvate kinase PKM2 inhibitor, exhibits anti-neuroinflammatory properties. It effectively suppresses LPS-induced production of proinflammatory nitric oxide (NO) and provides protection to immunologically active BV-2 cells with an IC50 value of 2.5 μM. Additionally, CIAC001 demonstrates anti-neuroinflammation effects in mouse models and attenuates chronic morphine-induced addiction [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 8-10 weeks | $ 1,520.00 | |
50 mg | 8-10 weeks | $ 1,980.00 | |
100 mg | 8-10 weeks | $ 2,500.00 |
Description | CIAC001, a pyruvate kinase PKM2 inhibitor, exhibits anti-neuroinflammatory properties. It effectively suppresses LPS-induced production of proinflammatory nitric oxide (NO) and provides protection to immunologically active BV-2 cells with an IC50 value of 2.5 μM. Additionally, CIAC001 demonstrates anti-neuroinflammation effects in mouse models and attenuates chronic morphine-induced addiction [1]. |
In vitro | CIAC001 (10 μM; 6 hours) inhibits LPS-induced (200 ng/mL) morphological changes in microglia in BV-2 cells [1]. |
In vivo | CIAC001 administered intraperitoneally at doses of 20 µg/kg and 0.2 mg/kg, once daily for seven days, dose-dependently mitigated naloxone-induced withdrawal jumping in morphine-dependent mice and significantly inhibited the development of behavior sensitization induced by morphine during the induction phase [1]. Additionally, CIAC001 at a dose of 20 mg/kg, given intraperitoneally once daily for seven days, did not notably impair memory or cognitive function in the Y maze test in mice [1]. |
Molecular Weight | 339.43 |
Formula | C20H25N3O2 |
CAS No. | 2649154-82-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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CIAC001 2649154-82-3 inhibitor inhibit