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Platyconic acid A

Name: Platyconic acid A
Brand: TargetMol
SKU: T40787
Rating: 4.5 (1 reviews)

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Catalog No. T40787Cas No. 68051-23-0

Platyconic Acid A, derived from changkil saponins extracted from platycodon grandiflorum, is a potent compound employed for studying the mitigation of airway inflammation.

Platyconic acid A

😃Good

Catalog No. T40787Cas No. 68051-23-0

Platyconic Acid A, derived from changkil saponins extracted from platycodon grandiflorum, is a potent compound employed for studying the mitigation of airway inflammation.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
25 mg	$846	Inquiry	Inquiry

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description

Platyconic Acid A, derived from changkil saponins extracted from platycodon grandiflorum, is a potent compound employed for studying the mitigation of airway inflammation.

In vitro

Platyconic Acid A, at concentrations ranging from 0.5 to 2 μM and applied for 30 minutes to A549 cells, concentration-dependently inhibits PMA-induced phosphorylation of NF-κB p65, IκBα, and Akt, and the degradation of IκBα[1]. In addition, a 24-hour exposure to the same concentration range of Platyconic Acid A notably reduces PMA-induced MUC5AC mRNA expression in A549 cells, also in a concentration-dependent manner[1]. This is supported by Western Blot Analysis, which confirms the inhibition of NF-κB p65, IκBα phosphorylation and degradation, and Akt phosphorylation; and RT-PCR results demonstrating a decrease in MUC5AC mRNA expression under the specified conditions[1].

Chemical Properties

Molecular Weight	1239.318
Formula	C₅₇H₉₀O₂₉
Cas No.	68051-23-0
Smiles	C[C@@H]1O[C@@H](O[C@@H]2[C@@H](O)[C@@H](O)CO[C@H]2OC(=O)[C@]23CCC(C)(C)C[C@H]2C2=CC[C@@H]4[C@@]5(C)C[C@H](O)[C@H](O[C@@H]6O[C@H](CO)[C@@H](O)[C@H](O)[C@H]6O)[C@@](CO)([C@@H]5CC[C@@]4(C)[C@]2(C)C[C@H]3O)C(O)=O)[C@H](O)[C@H](O)[C@H]1O[C@@H]1OC[C@@H](O)[C@H](O[C@@H]2OC[C@](O)(CO)[C@H]2O)[C@H]1O
Relative Density.	1.59 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Platyconic acid A