Powder: -20°C for 3 years | In solvent: -80°C for 1 year
O-Demethyl apremilast is an active metabolite of the phosphodiesterase 4 (PDE4) inhibitor apremilast .1It inhibits the activity of PDE4 isolated from U937 cells and LPS-induced TNF-α production in isolated human peripheral blood mononuclear cells (PBMCs; IC50s = 8.3 and 5.6 μM, respectively). O-Demethyl apremilast is also an oxidative degradation product of apremilast.2,3
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | 35 days | $ 155.00 | |
10 mg | 35 days | $ 288.00 | |
25 mg | 35 days | $ 675.00 |
Description | O-Demethyl apremilast is an active metabolite of the phosphodiesterase 4 (PDE4) inhibitor apremilast .1It inhibits the activity of PDE4 isolated from U937 cells and LPS-induced TNF-α production in isolated human peripheral blood mononuclear cells (PBMCs; IC50s = 8.3 and 5.6 μM, respectively). O-Demethyl apremilast is also an oxidative degradation product of apremilast.2,3 |
Molecular Weight | 446.47 |
Formula | C21H22N2O7S |
CAS No. | 1384441-38-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO:PBS (pH 7.2) (1:2): 0.3 mg/mL
DMSO: 30 mg/mL
DMF: 30 mg/mL
You can also refer to dose conversion for different animals. More
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O-Demethyl Apremilast 1384441-38-6 O Demethyl Apremilast ODemethyl Apremilast inhibitor inhibit