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Aminohexylgeldanamycin

Name: Aminohexylgeldanamycin
Brand: TargetMol
SKU: T37377
Rating: 4.5 (1 reviews)

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Catalog No. T37377Cas No. 485395-71-9

Aminohexylgeldanamycin (AHGDM), a derivative of Geldanamycin, is a highly effective inhibitor of HSP90. It exhibits considerable antiangiogenic and antitumor properties[1].

Aminohexylgeldanamycin

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Catalog No. T37377Cas No. 485395-71-9

Aminohexylgeldanamycin (AHGDM), a derivative of Geldanamycin, is a highly effective inhibitor of HSP90. It exhibits considerable antiangiogenic and antitumor properties[1].

Pack Size	Price	Availability
25 mg	$920	6-8 weeks
50 mg	$1,180	6-8 weeks
100 mg	$1,790	6-8 weeks

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Product Introduction

Bioactivity

Description	Aminohexylgeldanamycin (AHGDM), a derivative of Geldanamycin, is a highly effective inhibitor of HSP90. It exhibits considerable antiangiogenic and antitumor properties[1].
In vitro	HPMA copolymer-aminohexylgeldanamycin conjugates are designed to target the GRP78 protein, which is expressed on the surface of prostate cancer cells[2].

Chemical Properties

Molecular Weight	644.8
Formula	C₃₄H₅₂N₄O₈
Cas No.	485395-71-9

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 200 mg/mL (310.17 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5509 mL	7.7543 mL	15.5087 mL	77.5434 mL
5 mM	0.3102 mL	1.5509 mL	3.1017 mL	15.5087 mL
10 mM	0.1551 mL	0.7754 mL	1.5509 mL	7.7543 mL
20 mM	0.0775 mL	0.3877 mL	0.7754 mL	3.8772 mL
50 mM	0.0310 mL	0.1551 mL	0.3102 mL	1.5509 mL
100 mM	0.0155 mL	0.0775 mL	0.1551 mL	0.7754 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc