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Propargyl-PEG4-5-nitrophenyl carbonate

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Catalog No. T16613Cas No. 1422540-81-5

Propargyl-PEG4-5-nitrophenyl carbonate is a polyethylene glycol (PEG) derivative designed as a linker for proteolysis targeting chimeras (PROTACs) synthesis [1].

Propargyl-PEG4-5-nitrophenyl carbonate

Propargyl-PEG4-5-nitrophenyl carbonate

😃Good
Catalog No. T16613Cas No. 1422540-81-5
Propargyl-PEG4-5-nitrophenyl carbonate is a polyethylene glycol (PEG) derivative designed as a linker for proteolysis targeting chimeras (PROTACs) synthesis [1].
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Product Introduction

Bioactivity
Description
Propargyl-PEG4-5-nitrophenyl carbonate is a polyethylene glycol (PEG) derivative designed as a linker for proteolysis targeting chimeras (PROTACs) synthesis [1].
In vitro
PROTACs consist of two distinct ligands linked together: one targeting an E3 ubiquitin ligase and the other the target protein. They utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
Chemical Properties
Molecular Weight397.38
FormulaC18H23NO9
Cas No.1422540-81-5
SmilesO=C(OC1=CC=C(C=C1)N(=O)=O)OCCOCCOCCOCCOCC#C
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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%
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

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