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Deltorphin 2

Name: Deltorphin 2
Brand: TargetMol
SKU: T7639
Price: 57 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7639Cas No. 122752-16-3

Alias Deltorphin II

Deltorphin 2 ([D-Ala2]-Deltorphin II) is an agonist of δ opioid receptor with an IC50 of 1 nM.

Deltorphin 2

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Catalog No. T7639Alias Deltorphin IICas No. 122752-16-3

Deltorphin 2 ([D-Ala2]-Deltorphin II) is an agonist of δ opioid receptor with an IC50 of 1 nM.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$57	In Stock	In Stock
5 mg	$177	In Stock	In Stock
10 mg	$327	In Stock	In Stock
25 mg	$555	In Stock	In Stock
50 mg	$798	In Stock	In Stock
100 mg	$1,090	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:>99.99%

Appearance:solid

Color:White

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COA LCMS

Product Introduction

Deltorphin 2 AI Summary

Deltorphin 2 is a substrate for the TP_TRANSPORTER and is taken up by Xenopus laevis oocytes with Km values of 137,000.0 nM and 330,000.0 nM, indicating varying degrees of affinity for the transporter. The compound exhibits high affinity for the delta opioid receptor (Ki = 1.3 nM) with potent inhibitory activity (IC50 = 0.37 nM) in mouse vas deferens. It also demonstrates moderate affinity for the mu opioid receptor (Ki = 500.0 nM) but has weak inhibitory activity (IC50 > 3000.0 nM) in guinea pig ileum/longitudinal muscle with myenteric plexus. Deltorphin 2 shows agonist activity at both mu-opioid receptor (MOR) and delta-opioid receptor (DOR), effectively stimulating [35S]-GTPgammaS binding in human U2OS cell membranes and wild-type mouse spinal cord membranes, with EC50 values ranging from 1.778 nM to 11.0 nM. It also demonstrates moderate to high efficacy in beta-arrestin recruitment assays (Emax values from 49.0% to 71.0%), indicating significant bioactivity as an opioid receptor agonist. Furthermore, Deltorphin 2 exhibits antitrichomonal activity against Trichomonas vaginalis, with a minimum inhibitory concentration (MIC) greater than 320,000.0 nM after 48 hours of incubation..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Deltorphin 2 ([D-Ala2]-Deltorphin II) is an agonist of δ opioid receptor with an IC50 of 1 nM.
Targets&IC50	δ opioid receptor:0.41 nM
Synonyms	Deltorphin II

Chemical Properties

Molecular Weight	782.88
Formula	C₃₈H₅₄N₈O₁₀
Cas No.	122752-16-3
Smiles	[C@H](CC1=CC=CC=C1)(C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N)=O)=O)C(C)C)=O)[C@H](C)C)=O)CCC(O)=O)=O)NC([C@H](NC([C@H](CC2=CC=C(O)C=C2)N)=O)C)=O
Relative Density.	1.272 g/cm3
Sequence	Tyr-Asp-Ala-Leu-Ala-Phe-Glu-Val-Val-Gly
Sequence Short	Y-{d-Ala}-FEVVG

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (57.48 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.2773 mL	6.3867 mL	12.7733 mL	63.8667 mL
5 mM	0.2555 mL	1.2773 mL	2.5547 mL	12.7733 mL
10 mM	0.1277 mL	0.6387 mL	1.2773 mL	6.3867 mL
20 mM	0.0639 mL	0.3193 mL	0.6387 mL	3.1933 mL
50 mM	0.0255 mL	0.1277 mL	0.2555 mL	1.2773 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc