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YW1128

Catalog No. T35547 CAS 2131223-64-6

YW1128 is an inhibitor of Wnt/β-catenin signaling with an IC50 value of 4.1 nM in a reporter assay.1 It decreases protein levels of β-catenin in the presence of the GSK3β inhibitor lithium chloride and increases protein levels of Axin1 in HEK293 cells. YW1128 decreases lipid accumulation and the expression of gluconeogenic and lipogenic genes in Huh7 cells. It decreases the hepatic expression of Wnt target genes, improves glucose tolerance, and prevents body weight increases and hepatic lipid accumulation in mice fed a high-fat diet, but not mice fed normal chow, when administered at a dose of 40 mg/kg every other day for 11 weeks.

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YW1128, CAS 2131223-64-6

Pack Size	Availability	Price/USD
1 mg	35 days	$ 155.00
5 mg	35 days	$ 695.00
10 mg	35 days	$ 1,340.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Molecular Weight	343.38
Formula	C20H17N5O
CAS No.	2131223-64-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 30 mg/mL

PBS (pH 7.2): 2 mg/mL

DMF: 30 mg/mL

DMSO: 30 mg/mL

References and Literature

1. Obianom, O.N., Ai, Y., Li, Y., et al. Triazole-based inhibitors of the Wnt/β-catenin signaling pathway improve glucose and lipid metabolism in diet-induced obese mice. J. Med. Chem. 62(2), 727-741 (2019).

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

YW1128 2131223-64-6 YW 1128 YW-1128 inhibitor inhibit

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