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4,9-Anhydrotetrodotoxin

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Catalog No. T37093Cas No. 13072-89-4
Alias 4,9-anhydro-TTX, 4,9-Anhydrotetrodotoxin

4,9-Anhydrotetrodotoxin (4,9-anhydro-TTX) is a derivative of TTX that selectively blocks inward sodium current through Nav1.6 voltage-activated sodium channels (IC50 = 7.8 nM in Xenopus oocytes). [1][2][3] It demonstrates IC50 values of 1.3, 0.34, 0.99, 78.5, 1.3, and >30 µM for Nav1.2, Nav1.3, Nav1.4, Nav1.5, Nav1.7, and Nav1.8, respectively.[1]

4,9-Anhydrotetrodotoxin

4,9-Anhydrotetrodotoxin

😃Good
Catalog No. T37093Alias 4,9-anhydro-TTX, 4,9-AnhydrotetrodotoxinCas No. 13072-89-4
4,9-Anhydrotetrodotoxin (4,9-anhydro-TTX) is a derivative of TTX that selectively blocks inward sodium current through Nav1.6 voltage-activated sodium channels (IC50 = 7.8 nM in Xenopus oocytes). [1][2][3] It demonstrates IC50 values of 1.3, 0.34, 0.99, 78.5, 1.3, and >30 µM for Nav1.2, Nav1.3, Nav1.4, Nav1.5, Nav1.7, and Nav1.8, respectively.[1]
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100 μg$85835 days
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Bioactivity
Description
4,9-Anhydrotetrodotoxin (4,9-anhydro-TTX) is a derivative of TTX that selectively blocks inward sodium current through Nav1.6 voltage-activated sodium channels (IC50 = 7.8 nM in Xenopus oocytes). [1][2][3] It demonstrates IC50 values of 1.3, 0.34, 0.99, 78.5, 1.3, and >30 µM for Nav1.2, Nav1.3, Nav1.4, Nav1.5, Nav1.7, and Nav1.8, respectively.[1]
Synonyms4,9-anhydro-TTX, 4,9-Anhydrotetrodotoxin
Chemical Properties
Molecular Weight301.25
FormulaC11H15N3O7
Cas No.13072-89-4
Relative Density.3.07g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: 1 mg/mL (3.32 mM), Sonication is recommended.
Ethanol: 5 mg/mL (16.6 mM), Sonication is recommended.
Solution Preparation Table
H2O/Ethanol
1mg5mg10mg50mg
1 mM3.3195 mL16.5975 mL33.1950 mL165.9751 mL
Ethanol
1mg5mg10mg50mg
5 mM0.6639 mL3.3195 mL6.6390 mL33.1950 mL
10 mM0.3320 mL1.6598 mL3.3195 mL16.5975 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords

4,9Anhydrotetrodotoxin4,9 Anhydrotetrodotoxin
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