store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Anti-inflammatory agent 51 is an amide/sulfonamide derivative with anti-inflammatory and potentially anti-tumor activity and inhibition of NF-κB activation, which can be used to study acute lung injury and ulcerative colitis.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 30.00 | |
2 mg | In stock | $ 40.00 | |
5 mg | In stock | $ 64.00 | |
10 mg | In stock | $ 106.00 | |
25 mg | In stock | $ 176.00 | |
50 mg | In stock | $ 262.00 | |
100 mg | In stock | $ 389.00 |
Description | Anti-inflammatory agent 51 is an amide/sulfonamide derivative with anti-inflammatory and potentially anti-tumor activity and inhibition of NF-κB activation, which can be used to study acute lung injury and ulcerative colitis. |
Targets&IC50 | IL-6:0.61 μM (J774A.1 cells), TNF-α:4.34 μM (J774A.1 cells) |
In vitro | Anti-inflammatory agent 51 (compound 11d) effectively reduces the release of IL-6 (IC50 value of 0.61 μM) and TNF-α (IC50 of 4.34 μM), and decreases the mRNA levels of cytokines in J774A.1 cells. Anti-inflammatory agent 51 restores IκBα and inhibits the translocation of phosphorylated p65 to the nucleus [1]. |
In vivo | Anti-inflammatory agent 51 (compound 11d) improves lipopolysaccharide (LPS)-induced acute lung injury (ALI) and alleviates dextran sulfate sodium (DSS)-induced ulcerative colitis in mice [1]. |
Molecular Weight | 498.51 |
Formula | C22H22N6O6S |
CAS No. | 2911610-03-0 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (100.30 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Anti-inflammatory agent 51 2911610-03-0 NF-Κb NF-κB Antiinflammatoryagent51 inhibitor inhibit