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Cinnamyl-3,4-dihydroxy-α-cyanocinnamate

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Catalog No. T60860Cas No. 132465-11-3
Alias CDC

Cinnamyl-3,4-dihydroxy-α-cyanocinnamate (CDC) is a potent 12/15-lipoxygenase (12/15-LO) inhibitor (IC50 = 9-25nm), studied for type 1 diabetes.

Cinnamyl-3,4-dihydroxy-α-cyanocinnamate

Cinnamyl-3,4-dihydroxy-α-cyanocinnamate

🥰Excellent
Catalog No. T60860Alias CDCCas No. 132465-11-3
Cinnamyl-3,4-dihydroxy-α-cyanocinnamate (CDC) is a potent 12/15-lipoxygenase (12/15-LO) inhibitor (IC50 = 9-25nm), studied for type 1 diabetes.
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2 mg$99-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Cinnamyl-3,4-dihydroxy-α-cyanocinnamate (CDC) is a potent 12/15-lipoxygenase (12/15-LO) inhibitor (IC50 = 9-25nm), studied for type 1 diabetes.
In vitro
High glucose or 12(S)-HETE significantly enhanced transendothelial dextran transport, an effect amplified when both were combined. The 12/15-LO inhibitor, CDC, partially reduced this enhanced dextran transport [1].
In vivo
Elevated glucose and 12(S)-hydroxyeicosatetraenoic acid (HETE) levels can modify phosphorylation levels of vascular endothelial (VE)-cadherin and β‐catenin without affecting their total protein expression. Conversely, the 12/15-LO inhibitor, Cinnamyl-3,4-dihydroxy-α-cyanocinnamate (CDC), counteracts the impact of high glucose on protein phosphorylation, thereby preserving the integrity of the endothelial cell barrier. These findings were substantiated by a mouse diabetes mellitus model [1].
SynonymsCDC
Chemical Properties
Molecular Weight321.33
FormulaC19H15NO4
Cas No.132465-11-3
SmilesOc1ccc(\C=C(/C#N)C(=O)OC\C=C\c2ccccc2)cc1O
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 40 mg/mL (124.48 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.22 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.1121 mL15.5603 mL31.1207 mL155.6033 mL
5 mM0.6224 mL3.1121 mL6.2241 mL31.1207 mL
10 mM0.3112 mL1.5560 mL3.1121 mL15.5603 mL
20 mM0.1556 mL0.7780 mL1.5560 mL7.7802 mL
50 mM0.0622 mL0.3112 mL0.6224 mL3.1121 mL
100 mM0.0311 mL0.1556 mL0.3112 mL1.5560 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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