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Cinnamyl-3,4-dihydroxy-α-cyanocinnamate
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Catalog No. T60860Cas No. 132465-11-3
Alias CDC
Cinnamyl-3,4-dihydroxy-α-cyanocinnamate (CDC) is a potent 12/15-lipoxygenase (12/15-LO) inhibitor (IC50 = 9-25nm), studied for type 1 diabetes.
Cinnamyl-3,4-dihydroxy-α-cyanocinnamate
😃Good
Catalog No. T60860Alias CDCCas No. 132465-11-3
Cinnamyl-3,4-dihydroxy-α-cyanocinnamate (CDC) is a potent 12/15-lipoxygenase (12/15-LO) inhibitor (IC50 = 9-25nm), studied for type 1 diabetes.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 2 mg | $99 | - | In Stock |
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| Description | Cinnamyl-3,4-dihydroxy-α-cyanocinnamate (CDC) is a potent 12/15-lipoxygenase (12/15-LO) inhibitor (IC50 = 9-25nm), studied for type 1 diabetes. |
| In vitro | High glucose or 12(S)-HETE significantly enhanced transendothelial dextran transport, an effect amplified when both were combined. The 12/15-LO inhibitor, CDC, partially reduced this enhanced dextran transport [1]. |
| In vivo | Elevated glucose and 12(S)-hydroxyeicosatetraenoic acid (HETE) levels can modify phosphorylation levels of vascular endothelial (VE)-cadherin and β‐catenin without affecting their total protein expression. Conversely, the 12/15-LO inhibitor, Cinnamyl-3,4-dihydroxy-α-cyanocinnamate (CDC), counteracts the impact of high glucose on protein phosphorylation, thereby preserving the integrity of the endothelial cell barrier. These findings were substantiated by a mouse diabetes mellitus model [1]. |
| Synonyms | CDC |
| Molecular Weight | 321.33 |
| Formula | C19H15NO4 |
| Cas No. | 132465-11-3 |
| Smiles | Oc1ccc(\C=C(/C#N)C(=O)OC\C=C\c2ccccc2)cc1O |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 40 mg/mL (124.48 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.22 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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