Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AZD 2066 hydrate is a selective, orally active, and brain-penetrant antagonist of mGluR5. It exhibits antinociceptive effects [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 10-14 weeks | $ 1,440.00 | |
50 mg | 10-14 weeks | $ 1,880.00 |
Description | AZD 2066 hydrate is a selective, orally active, and brain-penetrant antagonist of mGluR5. It exhibits antinociceptive effects [1]. |
In vitro | AZD 2066, at concentrations ranging from 1-10 μM, effectively inhibits the Ca2+ response, demonstrating IC50 values of 27.2±9.1 nM in mGlu5/HEK cells, 3.56±0.52 nM in striatal cultures, 96.2±17.8 nM in hippocampal cultures, and 380±78.0 nM in cortical cultures. Additionally, this compound suppresses the oscillatory Ca2+ response induced by DHPG and blocks the effects of either DHPG or Quis in mGlu5/HEK cells. However, it is less effective in striatal neurons. |
In vivo | AZD 2066 (0.03-30 mg/kg; p.o.) demonstrates dose-dependent discriminative effects in male Wistar rats weighing 240-250g. Administered orally, the compound elicited a complete and dose-proportional response specific to AZD9272 60 minutes post-administration, indicating its activity at various dosages [1]. |
Molecular Weight | 386.33 |
Formula | C19H18ClN5O3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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AZD 2066 hydrate inhibitor inhibit