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SMD-3040

Name: SMD-3040
Brand: TargetMol
SKU: T79820
Rating: 4.5 (1 reviews)

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Catalog No. T79820Cas No. 3033109-92-8

Alias SMD3040, SMD 3040

SMD-3040 is a potent and selective SMARCA2 PROTAC degrader that achieves efficient target protein elimination with a DC50 of 12 nM and a Dmax of 91%, leading to robust inhibition of tumor cell proliferation and pronounced antitumor activity, and is enabled by rational assembly of a SMARCA2/4 ligand and a VHL ligand, supporting its application in melanoma and broader oncology research.

SMD-3040

😃Good

Catalog No. T79820Alias SMD3040, SMD 3040Cas No. 3033109-92-8

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 mg	Inquiry	Inquiry	Inquiry
50 mg	Inquiry	Inquiry	Inquiry

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	SMD-3040 is a potent and selective SMARCA2 PROTAC degrader that achieves efficient target protein elimination with a DC50 of 12 nM and a Dmax of 91%, leading to robust inhibition of tumor cell proliferation and pronounced antitumor activity, and is enabled by rational assembly of a SMARCA2/4 ligand and a VHL ligand, supporting its application in melanoma and broader oncology research.
In vitro	In proliferation assays utilizing SMARCA4-deficient cancer cell lines (specifically SK-Mel-5, H838, and A549), SMD-3040 was administered over a 7-day treatment period. The compound exhibited potent antiproliferative effects with GI50 values ranging from 8.8 to 119 nM [1].
In vivo	To evaluate antitumor efficacy in a physiological context, a mouse model harboring human melanoma xenografts was employed. SMD-3040 was administered intravenously at dosages ranging from 25 to 50 mg/kg, following a schedule of twice-weekly injections for a duration of two weeks. This treatment regimen led to a significant suppression of tumor growth in the xenograft model [1].
Synonyms	SMD3040, SMD 3040

Chemical Properties

Molecular Weight	943.21
Formula	C₅₂H₆₆N₁₀O₅S
Cas No.	3033109-92-8
Smiles	C(N1CC2(C1)CCC(CC2)N3C=C(C=N3)C=4C=C(N=NC4N)C5=C(O)C=CC=C5)[C@H]6CC[C@H](C(N[C@H](C(=O)N7[C@H](C(N[C@@H](C)C8=CC=C(C=C8)C9=C(C)N=CS9)=O)C[C@@H](O)C7)C(C)(C)C)=O)CC6

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (84.82 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.0602 mL	5.3010 mL	10.6021 mL	53.0105 mL
5 mM	0.2120 mL	1.0602 mL	2.1204 mL	10.6021 mL
10 mM	0.1060 mL	0.5301 mL	1.0602 mL	5.3010 mL
20 mM	0.0530 mL	0.2651 mL	0.5301 mL	2.6505 mL
50 mM	0.0212 mL	0.1060 mL	0.2120 mL	1.0602 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline /PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Stock solution preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

mix well and clarify

The above example illustrates how to use "In Vivo Formulation Calculator" and does not represent a recommended formulation for any specific compound. Please select an appropriate dissolution method based on your experimental animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc