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SMD-3040

Name: SMD-3040
Brand: TargetMol
SKU: T79820
Rating: 4.5 (1 reviews)

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Catalog No. T79820Cas No. 3033109-92-8

Alias SMD3040, SMD 3040

SMD-3040 is a potent and selective SMARCA2 PROTAC degrader that achieves efficient target protein elimination with a DC50 of 12 nM and a Dmax of 91%, leading to robust inhibition of tumor cell proliferation and pronounced antitumor activity, and is enabled by rational assembly of a SMARCA2/4 ligand and a VHL ligand, supporting its application in melanoma and broader oncology research.

SMD-3040

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Catalog No. T79820Alias SMD3040, SMD 3040Cas No. 3033109-92-8

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 mg	Inquiry	Inquiry	Inquiry
50 mg	Inquiry	Inquiry	Inquiry

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	SMD-3040 is a potent and selective SMARCA2 PROTAC degrader that achieves efficient target protein elimination with a DC50 of 12 nM and a Dmax of 91%, leading to robust inhibition of tumor cell proliferation and pronounced antitumor activity, and is enabled by rational assembly of a SMARCA2/4 ligand and a VHL ligand, supporting its application in melanoma and broader oncology research.
In vitro	In proliferation assays utilizing SMARCA4-deficient cancer cell lines (specifically SK-Mel-5, H838, and A549), SMD-3040 was administered over a 7-day treatment period. The compound exhibited potent antiproliferative effects with GI50 values ranging from 8.8 to 119 nM [1].
In vivo	To evaluate antitumor efficacy in a physiological context, a mouse model harboring human melanoma xenografts was employed. SMD-3040 was administered intravenously at dosages ranging from 25 to 50 mg/kg, following a schedule of twice-weekly injections for a duration of two weeks. This treatment regimen led to a significant suppression of tumor growth in the xenograft model [1].
Synonyms	SMD3040, SMD 3040

Chemical Properties

Molecular Weight	943.21
Formula	C₅₂H₆₆N₁₀O₅S
Cas No.	3033109-92-8
Smiles	C(N1CC2(C1)CCC(CC2)N3C=C(C=N3)C=4C=C(N=NC4N)C5=C(O)C=CC=C5)[C@H]6CC[C@H](C(N[C@H](C(=O)N7[C@H](C(N[C@@H](C)C8=CC=C(C=C8)C9=C(C)N=CS9)=O)C[C@@H](O)C7)C(C)(C)C)=O)CC6

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (84.82 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.0602 mL	5.3010 mL	10.6021 mL	53.0105 mL
5 mM	0.2120 mL	1.0602 mL	2.1204 mL	10.6021 mL
10 mM	0.1060 mL	0.5301 mL	1.0602 mL	5.3010 mL
20 mM	0.0530 mL	0.2651 mL	0.5301 mL	2.6505 mL
50 mM	0.0212 mL	0.1060 mL	0.2120 mL	1.0602 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc