LAG-3 Protein, Human, Recombinant

Catalog No. TMPY-04939

LAG-3 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 45.3 kDa and the accession number is P18627-1.

LAG-3 Protein, Human, Recombinant

Catalog No. TMPY-04939

LAG-3 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 45.3 kDa and the accession number is P18627-1.

Pack Size	Price	Availability
5 μg	$47	7-10 days
10 μg	$74	7-10 days
20 μg	$118	7-10 days
50 μg	$228	In Stock
100 μg	$392	7-10 days
200 μg	$670	7-10 days
500 μg	$1,350	7-10 days

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Product Information

Biological Activity	Immobilized Recombinant Human LAG3 / CD223 / Lymphocyte activation gene 3 Protein (ECD) at 2μg/mL (100μL/well) can bind Anti-LAG3(BMS)-IgG4 Antibody , the EC50 is 45-130 ng/mL.
Description	LAG-3 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 45.3 kDa and the accession number is P18627-1.
Species	Human
Expression System	HEK293 Cells
Tag	Tag Free
Accession Number	P18627-1
Synonyms	lymphocyte-activation gene 3,LAG-3,CD223
Construction	A DNA sequence encoding the human LAG3 (NP_002277.4) (Met1-Arg440) was expressed. Predicted N terminal: Leu 23
Protein Purity	> 90 % as determined by SDS-PAGE. > 95 % as determined by SEC-HPLC.
Molecular Weight	45.3 kDa (predicted); 56.1 kDa (reducing condition, due to glycosylation)
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice.
Research Background	LAG3 (Lymphocyte Activating 3) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. LAG3, also known as CD223 and Lymphocyte activation gene 3, belongs to the immunoglobulin (Ig) superfamily. The LAG3 gene contains 8 exons. It is selectively expressed in activated T and NK cells. LAG3 contains 4 extracellular Ig-like domains and has a negative regulatory function in T cells. It also acts as a new marker of T cell-induced B cell activation. As a soluble molecule, LAG3 activates antigen-presenting cells through MHC class II signaling, leading to increased antigen-specific T-cell responses in vivo. Diseases associated with LAG3 include Smoldering Myeloma and Kyphoscoliotic Heart Disease.Cancer ImmunotherapyCo-inhibitory Immune Checkpoint TargetsImmune CheckpointImmune Checkpoint TargetsImmunotherapyTargeted Therapy