LAG-3 Protein, Human, Recombinant

Catalog No. TMPY-04939 Copy Product Info

LAG-3 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 45.3 kDa and the accession number is P18627-1.

LAG-3 Protein, Human, Recombinant

Catalog No. TMPY-04939

Copy Product Info

LAG-3 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 45.3 kDa and the accession number is P18627-1.

Pack Size	Price	USA Stock	Global Stock
5 μg	$47	7-10 days	7-10 days
10 μg	$74	7-10 days	7-10 days
20 μg	$118	7-10 days	7-10 days
50 μg	$228	-	In Stock
100 μg	$392	7-10 days	7-10 days
200 μg	$670	7-10 days	7-10 days
500 μg	$1,350	7-10 days	7-10 days

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For In stock only · Estimated delivery:USA Stock (1-2 days) Global Stock (5-7 days)

For research use only—not for human use. No sales to individuals. Use as intended only.

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COA User Guide of Recombinant Proteins

Product Information

Biological Activity	Immobilized Recombinant Human LAG3 / CD223 / Lymphocyte activation gene 3 Protein (ECD) at 2μg/mL (100μL/well) can bind Anti-LAG3(BMS)-IgG4 Antibody , the EC50 is 45-130 ng/mL.
Description	LAG-3 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 45.3 kDa and the accession number is P18627-1.
Species	Human
Expression System	HEK293 Cells
Tag	Tag Free
Accession Number	P18627-1
Synonyms	lymphocyte-activation gene 3,LAG-3,CD223
Construction	A DNA sequence encoding the human LAG3 (NP_002277.4) (Met1-Arg440) was expressed. Predicted N terminal: Leu 23
Protein Purity	> 90 % as determined by SDS-PAGE. > 95 % as determined by SEC-HPLC.
Molecular Weight	45.3 kDa (predicted); 56.1 kDa (reducing condition, due to glycosylation)
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	Reconstituted with sterile deionized water to 0.25 mg/mL. Reconstitution conditions may vary depending on the lot.
Stability & Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Research Background	LAG3 (Lymphocyte Activating 3) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. LAG3, also known as CD223 and Lymphocyte activation gene 3, belongs to the immunoglobulin (Ig) superfamily. The LAG3 gene contains 8 exons. It is selectively expressed in activated T and NK cells. LAG3 contains 4 extracellular Ig-like domains and has a negative regulatory function in T cells. It also acts as a new marker of T cell-induced B cell activation. As a soluble molecule, LAG3 activates antigen-presenting cells through MHC class II signaling, leading to increased antigen-specific T-cell responses in vivo. Diseases associated with LAG3 include Smoldering Myeloma and Kyphoscoliotic Heart Disease.Cancer ImmunotherapyCo-inhibitory Immune Checkpoint TargetsImmune CheckpointImmune Checkpoint TargetsImmunotherapyTargeted Therapy