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Icariside I

Name: Icariside I
Brand: TargetMol
SKU: T3808
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3808Cas No. 56725-99-6

Alias Lcariside I, Icarisid I, Icariin I

Icariside I (Lcariside I) is isolated from Epimedium herb. It can stimulate osteogenic differentiation of BMSCs and inhibit bone resorption activity of osteoclasts.

Icariside I

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Purity: 99.47%

Catalog No. T3808Alias Lcariside I, Icarisid I, Icariin ICas No. 56725-99-6

Icariside I (Lcariside I) is isolated from Epimedium herb. It can stimulate osteogenic differentiation of BMSCs and inhibit bone resorption activity of osteoclasts.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$30	In Stock	In Stock
5 mg	$59	In Stock	In Stock
10 mg	$83	In Stock	In Stock
25 mg	$135	In Stock	In Stock
50 mg	$198	In Stock	In Stock
100 mg	$292	-	In Stock
200 mg	$433	-	In Stock
1 mL x 10 mM (in DMSO)	$67	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.47%

Color:Yellow

Resource Download

COA HPLC HNMR

Product Introduction

Icariside I AI Summary

Icariside I exhibits bioactivity in reversing P-gp-mediated multidrug resistance in human MCF7/ADR cells. The compound's effects were evaluated through modulation factors, which are the ratios of adriamycin IC50 without the compound to IC50 with the compound at concentrations of 1 µM, 10 µM, and 25 µM over 72 hours using an MTT assay. The modulation factors reported were 1.41 at 1 µM, 1.49 at 10 µM, and 1.62 at 25 µM, indicating stronger modulation at higher concentrations. Additionally, Icariside I showed cytotoxicity against MCF7/ADR cells with an IC50 value of 60780.0 nM after 72 hours as measured by the MTT assay..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Icariside I (Lcariside I) is isolated from Epimedium herb. It can stimulate osteogenic differentiation of BMSCs and inhibit bone resorption activity of osteoclasts.
Synonyms	Lcariside I, Icarisid I, Icariin I

Chemical Properties

Molecular Weight	530.52
Formula	C₂₇H₃₀O₁₁
Cas No.	56725-99-6
Smiles	COc1ccc(cc1)-c1oc2c(CC=C(C)C)c(O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)cc(O)c2c(=O)c1O
Relative Density.	1.475g/cm3

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 62.5 mg/mL (117.81 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8849 mL	9.4247 mL	18.8494 mL	94.2472 mL
5 mM	0.3770 mL	1.8849 mL	3.7699 mL	18.8494 mL
10 mM	0.1885 mL	0.9425 mL	1.8849 mL	9.4247 mL
20 mM	0.0942 mL	0.4712 mL	0.9425 mL	4.7124 mL
50 mM	0.0377 mL	0.1885 mL	0.3770 mL	1.8849 mL
100 mM	0.0188 mL	0.0942 mL	0.1885 mL	0.9425 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc