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Licoisoflavone B

Name: Licoisoflavone B
Brand: TargetMol
SKU: TN1864
Price: 147 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TN1864Cas No. 66056-30-2

Licoisoflavone B is an isoflavonoid from Glycyrrhiza uralensis Fisch.Licoisoflavone B inhibits lipid peroxidation and inhibits human cytochrome P450 enzymes (CYP2C8 and CYP2C9).

Licoisoflavone B

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Purity: 99.79%

Catalog No. TN1864Cas No. 66056-30-2

Licoisoflavone B is an isoflavonoid from Glycyrrhiza uralensis Fisch.Licoisoflavone B inhibits lipid peroxidation and inhibits human cytochrome P450 enzymes (CYP2C8 and CYP2C9).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$147	-	In Stock
5 mg	$455	-	In Stock
10 mg	$655	-	In Stock
25 mg	$987	-	In Stock
50 mg	$1,360	-	In Stock
1 mL x 10 mM (in DMSO)	$463	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.79%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description

Licoisoflavone B is an isoflavonoid from Glycyrrhiza uralensis Fisch.Licoisoflavone B inhibits lipid peroxidation and inhibits human cytochrome P450 enzymes (CYP2C8 and CYP2C9).

In vitro

We present the results of an in vitro investigation of the inhibitory effects of licoisoflavone A and Licoisoflavone B and sophoraisoflavone A isolated from Sophra mooracroftiana BETH ex BAKER on copper-induced protein oxidative modification of mice brain homogenate in vitro. Although inhibitory effect of sophoraisoflavone A was stronger than those of licoisoflavone A and Licoisoflavone B, genistein as a related isoflavone, and mannitol as a hydroxy radical scavenger, inhibitory effects of licoisoflavone A and Licoisoflavone B were weaker than those of genistein and mannitol[1]

Chemical Properties

Molecular Weight	352.34
Formula	C₂₀H₁₆O₆
Cas No.	66056-30-2
Smiles	O=C1C(=COC=2C=C(O)C=C(O)C12)C=3C=CC=4OC(C=CC4C3O)(C)C
Relative Density.	1.443 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from direct sunlight,keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (113.53 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (2.84 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8382 mL	14.1908 mL	28.3817 mL	141.9084 mL
5 mM	0.5676 mL	2.8382 mL	5.6763 mL	28.3817 mL
10 mM	0.2838 mL	1.4191 mL	2.8382 mL	14.1908 mL
20 mM	0.1419 mL	0.7095 mL	1.4191 mL	7.0954 mL
50 mM	0.0568 mL	0.2838 mL	0.5676 mL	2.8382 mL
100 mM	0.0284 mL	0.1419 mL	0.2838 mL	1.4191 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc