Powder: -20°C for 3 years | In solvent: -80°C for 1 year
(Rac)-Indoximod (1-Methyl-DL-tryptophan) is a potent inhibitor of indoleamine 2,3-dioxygenase (IDO). Combined treatment with IFN-γ and (Rac)-Indoximod significantly suppresses the activity of α-SMA-expressing human cardiac myofibroblasts (hCMs) and promotes apoptosis by up-regulating the genes IRF-1, Fas, and FasL. Moreover, this co-treatment effectively improves cardiac fibrosis[1].
Pack Size | Availability | Price/USD | Quantity |
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25 mg | 6-8 weeks | Inquiry |
Description | (Rac)-Indoximod (1-Methyl-DL-tryptophan) is a potent inhibitor of indoleamine 2,3-dioxygenase (IDO). Combined treatment with IFN-γ and (Rac)-Indoximod significantly suppresses the activity of α-SMA-expressing human cardiac myofibroblasts (hCMs) and promotes apoptosis by up-regulating the genes IRF-1, Fas, and FasL. Moreover, this co-treatment effectively improves cardiac fibrosis[1]. |
In vitro | (Rac)-Indoximod (1-Methyl-DL-tryptophan; 0.5 mM; 3 days) mitigates the effects of tryptophan depletion, partially countering the growth-suppressive effects of IFN-γ, yet eventually leads to cell death regardless of tryptophan levels. In a Cell Viability Assay using human cardiac myofibroblasts (hCMs) at a concentration of 0.5 mM over 3 days, it was observed that while IFN-γ induced growth inhibition was partly alleviated by the second day, cell viability notably declined by the third day. |
Molecular Weight | 218.25 |
Formula | C12H14N2O2 |
CAS No. | 26988-72-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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(Rac)-Indoximod 26988-72-7 inhibitor inhibit