Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Telomerase-IN-4 is a potent inhibitor of telomerase with antiproliferative properties and induces apoptosis [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,520.00 | |
50 mg | 6-8 weeks | $ 1,980.00 | |
100 mg | 6-8 weeks | $ 2,500.00 |
Description | Telomerase-IN-4 is a potent inhibitor of telomerase with antiproliferative properties and induces apoptosis [1]. |
In vitro | Telomerase-IN-4 (compound 8e; 0.1-100 μg/mL; 72 h) exhibits antitumor activity against two cancer cell lines, with IC50 values of 9.47 μg/mL in MCF-7 cells and 17.09 μg/mL in A549 cells [1]. At a concentration of 9.467 μg/mL, administered for 48 hours, Telomerase-IN-4 induces cell cycle arrest at the S phase and promotes apoptosis in MCF-7 cells [1]. |
In vivo | Telomerase-IN-4, administered intraperitoneally at a dose of 5 mg/kg three times weekly over two weeks, exhibited anticancer activity by inhibiting tumor growth in albino female Swiss mice [1]. |
Molecular Weight | 406.52 |
Formula | C21H18N4OS2 |
CAS No. | 2892295-10-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Telomerase-IN-4 2892295-10-0 Apoptosis inhibitor inhibit