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2-Hydroxy-3-methylanthraquinone

Name: 2-Hydroxy-3-methylanthraquinone
Brand: TargetMol
SKU: TN1211
Rating: 4.5 (1 reviews)

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Catalog No. TN1211 Copy Product Info

Purity: 99.60%

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2-Hydroxy-3-methylanthraquinone is a natural anthraquinone derivative that exhibits cytotoxic and pro-apoptotic activity against various tumor cells. It modulates SRC-related signaling and the activity of the IL-6/JAK2/STAT3 pathway, and induces a decrease in mitochondrial membrane potential and Caspase-3-dependent apoptosis. It can also influence MAPK-related signaling pathways, including the phosphorylation levels of p38MAPK and ERK1/2. 2-Hydroxy-3-methylanthraquinone is also commonly used in research related to anthraquinone chemistry, redox properties, and the pharmacological activity of natural products.

Cas No. 17241-40-6

Pack Size	Price	USA Stock	Global Stock	Quantity
5 mg	$550	Inquiry	Inquiry

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.60%

Appearance:Solid

Color:Yellow

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COA

Product Introduction

Bioactivity

Description

In vitro

2-Hydroxy-3-methylanthraquinone (Compound 1) inhibits the tyrosine kinase activity of pp60c-src, GST-v-src, and SPC-A-1 total protein, with IC₅₀ values of approximately 20 μM, 33 μM, and 67 μM, respectively [1].
2-Hydroxy-3-methylanthraquinone (48 h) inhibits the proliferation of HepG2, SPC-A-1, and Bcap37 cancer cells, with IC50 values of 51 μM, 66 μM, and 57 μM, respectively; however, its activity against SW480 cells is significantly lower (IC50 >125 μM)[1].
2-Hydroxy-3-methylanthraquinone (10 μM; 48 h) induces apoptosis in HepG2 cells, as evidenced by nuclear chromatin condensation and a significant increase in the apoptotic cell population [1].
2-Hydroxy-3-methylanthraquinone (2–12 h) causes a time-dependent decrease in mitochondrial membrane potential in HepG2 cells, with significant reductions observed at 6 h and 12 h [1].
2-Hydroxy-3-methylanthraquinone (10 μM; 0–24 h) induces time-dependent activation of caspase-3 in HepG2 cells, with a significant increase in activity observed between 6 h and 24 h [1].

Chemical Properties

Molecular Weight	238.24
Formula	C₁₅H₁₀O₃
Cas No.	17241-40-6
Smiles	O=C1C=2C=CC=CC2C(=O)C3=CC(=C(O)C=C13)C
Relative Density.	1.371 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Store under nitrogen, Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 4 mg/mL (16.79 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.1974 mL	20.9872 mL	41.9745 mL	209.8724 mL
5 mM	0.8395 mL	4.1974 mL	8.3949 mL	41.9745 mL
10 mM	0.4197 mL	2.0987 mL	4.1974 mL	20.9872 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

p38MAPKp38 MAPKp38ERKCaspase2-Hydroxy-3-methylanthraquinone2Hydroxy3methylanthraquinone2 Hydroxy 3 methylanthraquinone

Related Tags: 2-Hydroxy-3-methylanthraquinone chemical structure | 2-Hydroxy-3-methylanthraquinone in vitro | 2-Hydroxy-3-methylanthraquinone formula | 2-Hydroxy-3-methylanthraquinone molecular weight