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Depatuxizumab
🥰Excellent
Catalog No. T78326Cas No. 1471999-69-5
Alias ABT-806, ABT806
Depatuxizumab is a humanised monoclonal antibody targeting EGFR with blood-brain barrier (BBB) permeability, capable of inhibiting the growth of xenograft tumours expressing mutant EGFR vIII and wild-type EGFR. It can be conjugated with the ADC molecule Depatuxizumab mafodotin for the study of glioblastoma (GBM) and head and neck squamous cell carcinoma (SCCHN).
Depatuxizumab
Depatuxizumab
🥰Excellent
Purity: 95%
Catalog No. T78326Alias ABT-806, ABT806Cas No. 1471999-69-5
Depatuxizumab is a humanised monoclonal antibody targeting EGFR with blood-brain barrier (BBB) permeability, capable of inhibiting the growth of xenograft tumours expressing mutant EGFR vIII and wild-type EGFR. It can be conjugated with the ADC molecule Depatuxizumab mafodotin for the study of glioblastoma (GBM) and head and neck squamous cell carcinoma (SCCHN).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $415 | In Stock | |
| 5 mg | $1,230 | In Stock | |
| 10 mg | $1,990 | In Stock |
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Concentration:5.88 mg/mL
Purity:95%
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Product Introduction
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Chemical Properties
| Description | Depatuxizumab is a humanised monoclonal antibody targeting EGFR with blood-brain barrier (BBB) permeability, capable of inhibiting the growth of xenograft tumours expressing mutant EGFR vIII and wild-type EGFR. It can be conjugated with the ADC molecule Depatuxizumab mafodotin for the study of glioblastoma (GBM) and head and neck squamous cell carcinoma (SCCHN). |
| In vivo | Depatuxizumab (10, 40 mg/kg, intraperitoneal injection, 3 times a week for 2 weeks) can significantly inhibit tumor growth in the U87MGde2-7 glioblastoma multiforme (GBM) model and A431 squamous cell carcinoma model of Nu/Nu mice. Depatuxizumab (10, 40 mg/kg, intraperitoneal injection, 3 times a week for 2 weeks) can inhibit tumor growth and pEGFR levels in the EGFRvIII-positive GBM-SN0199-PDX model of NSG mice. [1] |
| Synonyms | ABT-806, ABT806 |
| Cas No. | 1471999-69-5 |
Storage & Solubility Information
| Storage | store at low temperature | store at -20°C | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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