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Depatuxizumab, a brain-penetrant, humanized anti-EGFR monoclonal antibody, selectively inhibits the growth of mutant EGFRvIII and wild-type EGFR xenograft models, and is utilized for research on cancer [1].
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Description | Depatuxizumab, a brain-penetrant, humanized anti-EGFR monoclonal antibody, selectively inhibits the growth of mutant EGFRvIII and wild-type EGFR xenograft models, and is utilized for research on cancer [1]. |
In vivo | Depatuxizumab administered intraperitoneally (i.p.) at doses of 10 and 40 mg/kg three times per week for two weeks significantly inhibited tumor growth in the U87MG delta-2-7 glioblastoma (GBM) variant model and the A431 epidermoid carcinoma model in Nu/Nu mice [1]. The same treatment regimen with depatuxizumab suppressed tumor growth and levels of phosphorylated EGFR (pEGFR) in the EGFRvIII-positive GBM-SN0199-PDX model in NSG mice [1]. Moreover, depatuxizumab demonstrated dose-dependent inhibition of tumor growth in the SCC15 tumor-bearing SCID Beige mouse model when administered at concentrations ranging from 2 to 40 mg/kg [1]. |
Synonyms | ABT-806 |
Molecular Weight | N/A |
CAS No. | 1471999-69-5 |
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Depatuxizumab 1471999-69-5 Angiogenesis JAK/STAT signaling Tyrosine Kinase/Adaptors EGFR ABT-806 ABT 806 ABT806 inhibitor inhibit