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Nortrachelogenin

Name: Nortrachelogenin
Brand: TargetMol
SKU: TN4675
Price: 106 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TN4675Cas No. 34444-37-6

Alias (-)-Wikstromol, (-)-Nortrachelogenin

Nortrachelogenin ((-)-Wikstromol), which can be extracted from Partrinia scabiosaefolia, has antifungal activity and induces membrane disruption and cysteinyl asparagin-dependent apoptosis.

Nortrachelogenin

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Purity: 99.86%

Catalog No. TN4675Alias (-)-Wikstromol, (-)-NortrachelogeninCas No. 34444-37-6

Nortrachelogenin ((-)-Wikstromol), which can be extracted from Partrinia scabiosaefolia, has antifungal activity and induces membrane disruption and cysteinyl asparagin-dependent apoptosis.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$106	In Stock	In Stock
5 mg	$297	In Stock	In Stock
10 mg	$442	In Stock	In Stock
25 mg	$717	-	In Stock
50 mg	$988	-	In Stock
1 mL x 10 mM (in DMSO)	$288	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.86%

Appearance:Solid

Color:White to Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Nortrachelogenin ((-)-Wikstromol), which can be extracted from Partrinia scabiosaefolia, has antifungal activity and induces membrane disruption and cysteinyl asparagin-dependent apoptosis.
In vitro	Methanolic extract of the root bark of carissa edulis showed anti-plasmodial activity against the chloroquin-senitive (D6) strains of plasmodium falciparum parasite with an IC50 value of 1.95 Dg/ml. From this extract, a lignan compound Nortrachelogenin was isolated and showed anti-plasmodium activity of 14.50 Dg/ml. The structure was determined on the basis of spectroscopic evidence.[1]
Synonyms	(-)-Wikstromol, (-)-Nortrachelogenin

Chemical Properties

Molecular Weight	374.38
Formula	C₂₀H₂₂O₇
Cas No.	34444-37-6
Smiles	COc1cc(C[C@H]2COC(=O)[C@]2(O)Cc2ccc(O)c(OC)c2)ccc1O
Relative Density.	1.370 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (146.91 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (2.67 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6711 mL	13.3554 mL	26.7108 mL	133.5541 mL
5 mM	0.5342 mL	2.6711 mL	5.3422 mL	26.7108 mL
10 mM	0.2671 mL	1.3355 mL	2.6711 mL	13.3554 mL
20 mM	0.1336 mL	0.6678 mL	1.3355 mL	6.6777 mL
50 mM	0.0534 mL	0.2671 mL	0.5342 mL	2.6711 mL
100 mM	0.0267 mL	0.1336 mL	0.2671 mL	1.3355 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc