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Mycophenolic acid sodium

Name: Mycophenolic acid sodium
Brand: TargetMol
SKU: T61099
Price: 37 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: Mycophenolate sodium) Copy Product Info

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Synonyms: Mycophenolate sodium

Catalog No. T61099 Copy Product Info

Purity: 99.97%

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Mycophenolic acid sodium is a potent uncompetitive inhibitor of inosine monophosphate dehydrogenase (IMPDH), exhibiting an EC50 value of 0.24 μM. Mycophenolic acid sodium demonstrates broad antiviral activity against RNA viruses, including influenza. Mycophenolic acid sodium additionally exhibits immunosuppressive, antiangiogenic, and antitumor activities. Mycophenolic acid sodium is widely utilized in virology, immunology, angiogenesis, and cancer biology research involving nucleotide biosynthesis regulation.

Cas No. 37415-62-6

Pack Size	Price	USA Stock	Global Stock	Quantity
50 mg	$37	-	In Stock
1 mL x 10 mM (in DMSO)	$58	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.97%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Mycophenolic acid sodium is a potent uncompetitive inhibitor of inosine monophosphate dehydrogenase (IMPDH), exhibiting an EC50 value of 0.24 μM. Mycophenolic acid sodium demonstrates broad antiviral activity against RNA viruses, including influenza. Mycophenolic acid sodium additionally exhibits immunosuppressive, antiangiogenic, and antitumor activities. Mycophenolic acid sodium is widely utilized in virology, immunology, angiogenesis, and cancer biology research involving nucleotide biosynthesis regulation.
Targets & IC50	IMPDH:0.24μM(EC50)
In vitro	Mycophenolic acid sodium has been demonstrated to possess antiviral properties against an array of RNA viruses, including influenza, dengue virus, Zika virus, rotavirus, CCHFV, and hantavirus [1]. Mycophenolic acid sodium (0.01-1 μM, 72 h) displays a selective inhibitory effect on the proliferation of endothelial cells and fibroblasts, with endothelial cells being more susceptible (IC 50 <500 nM) to its antimitotic effects [2]. In contrast, fibroblasts showed a higher tolerance (IC 50 <1 μM). Among human tumor cell lines tested, A549 non-small cell lung cancer and PC3 prostate cancer cells manifested moderate sensitivity (IC 50 >1 μM), whereas U87 glioblastoma cells were resistant to up to 1 μM of mycophenolic acid sodium treatment [2]. Mycophenolic acid sodium (0.05-2 μM, 18 h) up-regulates NDRG1 while exhibits a down-regulation of HDAC2 and MYC in a dose-dependent[2].
In vivo	Mycophenolic acid sodium (120 mg/kg; oral gavage; b.i.d.) exhibits potent anti-tumor activity by altering the tumor microenvironment and significantly inhibiting U87 tumor growth in BALB/c nude mice [2]. Using an athymic 8-week-old, 20 g BALB/c nu/nu mouse model with a Mycophenolic acid-resistant U87 tumor, 120 mg/kg of MMF (the morpholinoethyl ester prodrug of Mycophenolic acid) was administered orally twice daily. After 14 days post-tumor implantation, the MMF-treated group showed a 70% reduction in tumor growth compared to controls. Furthermore, MMF treatment significantly decreased microvessel density (by 44%) and pericyte coverage (by 78%), as indicated by CD31 and α-smooth muscle actin staining, respectively, suggesting impaired tumor vascularization and underscoring its efficacy against tumor proliferation [2].
Synonyms	Mycophenolate sodium

Chemical Properties

Molecular Weight	342.32
Formula	C₁₇H₁₉NaO₆
Cas No.	37415-62-6
Smiles	CC1=C2C(C(OC2)=O)=C(C(C/C=C(C)/CCC([O-])=O)=C1OC)O.[Na+]

Storage & Solubility Information

Storage

Keep away from moisture, Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 80 mg/mL (233.7 mM), Sonication is recommended.

DMSO: 140 mg/mL (408.97 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9212 mL	14.6062 mL	29.2124 mL	146.0622 mL
5 mM	0.5842 mL	2.9212 mL	5.8425 mL	29.2124 mL
10 mM	0.2921 mL	1.4606 mL	2.9212 mL	14.6062 mL
20 mM	0.1461 mL	0.7303 mL	1.4606 mL	7.3031 mL
50 mM	0.0584 mL	0.2921 mL	0.5842 mL	2.9212 mL
100 mM	0.0292 mL	0.1461 mL	0.2921 mL	1.4606 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Related Tags: Mycophenolic acid sodium chemical structure | Mycophenolic acid sodium in vivo | Mycophenolic acid sodium in vitro | Mycophenolic acid sodium formula | Mycophenolic acid sodium molecular weight