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Berberrubine chloride
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Catalog No. T4S0795Cas No. 15401-69-1
Alias Beroline Chloride, 9-Berberoline Chloride
1. Berberrubine chloride (9-Berberoline Chloride) has antitumor activity. 2. Berberrubine has antidiabetic activity. 3. Berberrubine dose-dependently inhibits IL-8 and MCP-1 protein levels in the media and mRNA expression of the cells stimulated with IL-1beta or TNF-alpha.
Berberrubine chloride
Copy Product Info🥰Excellent
Purity: 99.11%
Catalog No. T4S0795Alias Beroline Chloride, 9-Berberoline ChlorideCas No. 15401-69-1
1. Berberrubine chloride (9-Berberoline Chloride) has antitumor activity. 2. Berberrubine has antidiabetic activity. 3. Berberrubine dose-dependently inhibits IL-8 and MCP-1 protein levels in the media and mRNA expression of the cells stimulated with IL-1beta or TNF-alpha.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 2 mg | $30 | In Stock | In Stock | |
| 5 mg | $44 | In Stock | In Stock | |
| 10 mg | $73 | In Stock | In Stock | |
| 25 mg | $147 | In Stock | In Stock | |
| 50 mg | $215 | In Stock | In Stock | |
| 100 mg | $318 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $48 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.11%
Appearance:Solid
Color:Yellow
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Product Introduction
Berberrubine chloride AI Summary
Berberrubine chloride exhibits lipophilicity with a log P value of -1.06 and shows its highest solubility in sodium phosphate buffer at pH 4.5. It has a pKa value of 5.0, indicating its ionization state under different pH conditions. The compound also has some binding affinity to bovine serum albumin.
In terms of biological activity, Berberrubine chloride demonstrates antiviral activity against Human immunodeficiency virus 1 NL4.3 by inhibiting p24 antigen production and reverse transcriptase activity. Moreover, it exhibits cytotoxicity against human CEM cells, although it has a therapeutic index suggesting a favorable margin of safety.
The compound has shown growth inhibition in various human tumor cell lines, including renal, non-small cell lung, leukemia, melanoma, ovarian, central nervous system, and colon cell lines, with GI50 values ranging from 10,000.0 nM to 100,000.0 nM. Specific cytotoxicity was observed against human HT-29 cells with an IC50 of 36,930.0 nM after 48 hours, but not significantly after 24 hours or against HepG2 cells. Additionally, it exhibits cytotoxicity against KB, Bel7402, BGC823, and HL60 cancer cell lines after 48 hours.
Berberrubine chloride also displays antioxidant activity with an EC50 value of 87,000.0 nM in DPPH assays, suggesting its potential application in neutralizing free radicals and in anti-oxidative processes. Overall, this compound shows promise in both anti-cancer and antiviral applications, warranting further investigation and development..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | 1. Berberrubine chloride (9-Berberoline Chloride) has antitumor activity. 2. Berberrubine has antidiabetic activity. 3. Berberrubine dose-dependently inhibits IL-8 and MCP-1 protein levels in the media and mRNA expression of the cells stimulated with IL-1beta or TNF-alpha. |
| Synonyms | Beroline Chloride, 9-Berberoline Chloride |
| Molecular Weight | 357.79 |
| Formula | C19H16ClNO4 |
| Cas No. | 15401-69-1 |
| Smiles | [Cl-].COc1ccc2cc3-c4cc5OCOc5cc4CC[n+]3cc2c1O |
| Relative Density. | no data available |
| Storage | keep away from moisture,store at low temperature,store under nitrogen | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | H2O: 2 mg/mL (5.59 mM), Sonication is recommended.  Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.: Soluble DMSO: 11.17 mg/mL (31.22 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
H2O/DMSO
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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