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Talviraline

Name: Talviraline
Brand: TargetMol
SKU: T28918
Price: 130 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T28918Cas No. 163451-80-7

Alias HBY 097, Bay10-8979, Bay-10-8979, Bay-108979, Bay108979, Bay 10-8979, Bay 108979

Talviraline (Bay 10-8979) is an RNA-induced DNA polymerase inhibitor.Talviraline is a potent inhibitor of HIV-1-induced cell killing and HIV-1 replication in a variety of human cell lines, as well as in fresh human peripheral blood lymphocytes and macrophages.

Talviraline

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Purity: 99.88%

Catalog No. T28918Alias HBY 097, Bay10-8979, Bay-10-8979, Bay-108979, Bay108979, Bay 10-8979, Bay 108979Cas No. 163451-80-7

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$130	In Stock	In Stock
5 mg	$320	In Stock	In Stock
10 mg	$480	In Stock	In Stock
25 mg	$786	In Stock	In Stock
50 mg	$1,080	In Stock	In Stock
100 mg	$1,480	-	In Stock
500 mg	$2,960	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.88%

ee:100%

Appearance:Solid

Color:Yellow

Resource Download

COA LCMS CSFC HNMR ORP

Product Introduction

Bioactivity

Description	Talviraline (Bay 10-8979) is an RNA-induced DNA polymerase inhibitor.Talviraline is a potent inhibitor of HIV-1-induced cell killing and HIV-1 replication in a variety of human cell lines, as well as in fresh human peripheral blood lymphocytes and macrophages.
Synonyms	HBY 097, Bay10-8979, Bay-10-8979, Bay-108979, Bay108979, Bay 10-8979, Bay 108979

Chemical Properties

Molecular Weight	340.46
Formula	C₁₅H₂₀N₂O₃S₂
Cas No.	163451-80-7
Smiles	C(OC(C)C)(=O)N1C=2C(NC(=S)[C@@H]1CSC)=CC=C(OC)C2
Relative Density.	1.30 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (146.86 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9372 mL	14.6860 mL	29.3720 mL	146.8601 mL
5 mM	0.5874 mL	2.9372 mL	5.8744 mL	29.3720 mL
10 mM	0.2937 mL	1.4686 mL	2.9372 mL	14.6860 mL
20 mM	0.1469 mL	0.7343 mL	1.4686 mL	7.3430 mL
50 mM	0.0587 mL	0.2937 mL	0.5874 mL	2.9372 mL
100 mM	0.0294 mL	0.1469 mL	0.2937 mL	1.4686 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc