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CD3 epsilon/CD3e Protein, Human, Recombinant (hFc & Avi), Biotinylated

Catalog No. TMPJ-00089
Synonyms: T-Cell Surface Antigen T3/Leu-4 ε Chain, T3E, T-Cell Surface Glycoprotein CD3 Epsilon Chain, T-Cell Surface Glycoprotein CD3 ε Chain, T-Cell Surface Antigen T3/Leu-4 Epsilon Chain, CD3E

T-Cell Surface Glycoprotein CD3 ε Chain (CD3ε) is a single-pass type I membrane protein. CD3ε contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3ε is a polypeptide encoded by the CD3E gene on chromosome 11 in humans. The T cell receptor-CD3 complex (TCR/CD3 complex) is involved in T-cell development and several intracellular signal-transduction pathways. This complex is critical for T-cell development and function, and represents one of the most complex transmembrane receptors. The T cell receptor-CD3 complex is unique in having ten cytoplasmic immunoreceptor tyrosine-based activation motifs (ITAMs). TCR/CD3 complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
CD3 epsilon/CD3e Protein, Human, Recombinant (hFc & Avi), Biotinylated
Pack Size Availability Price/USD Quantity
20 μg 5 days $ 355.00
100 μg 5 days $ 963.00
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Biological Description
Technical Params
Product Properties
Description T-Cell Surface Glycoprotein CD3 ε Chain (CD3ε) is a single-pass type I membrane protein. CD3ε contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3ε is a polypeptide encoded by the CD3E gene on chromosome 11 in humans. The T cell receptor-CD3 complex (TCR/CD3 complex) is involved in T-cell development and several intracellular signal-transduction pathways. This complex is critical for T-cell development and function, and represents one of the most complex transmembrane receptors. The T cell receptor-CD3 complex is unique in having ten cytoplasmic immunoreceptor tyrosine-based activation motifs (ITAMs). TCR/CD3 complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways.
Species Human
Expression System Human Cells
Tag C-Fc-Avi
Accession Number P07766
Synonyms T-Cell Surface Antigen T3/Leu-4 ε Chain, T3E, T-Cell Surface Glycoprotein CD3 Epsilon Chain, T-Cell Surface Glycoprotein CD3 ε Chain, T-Cell Surface Antigen T3/Leu-4 Epsilon Chain, CD3E
Amino Acid Asp23-Asp126
Construction Biotinylated Recombinant Human T-cell Surface Glycoprotein CD3 Epsilon Chain is produced by our Mammalian expression system and the target gene encoding Asp23-Asp126 is expressed with a human IgG1 Fc, Avi tag at the C-terminus.
Protein Purity Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
Molecular Weight 45-60 KDa, reducing conditions
Endotoxin Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Reconstitution Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. 
Stability & Storage

Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below.
Research Background T-Cell Surface Glycoprotein CD3 ε Chain (CD3ε) is a single-pass type I membrane protein. CD3ε contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3ε is a polypeptide encoded by the CD3E gene on chromosome 11 in humans. The T cell receptor-CD3 complex (TCR/CD3 complex) is involved in T-cell development and several intracellular signal-transduction pathways. This complex is critical for T-cell development and function, and represents one of the most complex transmembrane receptors. The T cell receptor-CD3 complex is unique in having ten cytoplasmic immunoreceptor tyrosine-based activation motifs (ITAMs). TCR/CD3 complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways.

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Keywords

CD3 epsilon/CD3e Protein, Human, Recombinant (hFc & Avi), Biotinylated T-Cell Surface Antigen T3/Leu-4 ε Chain T3E T-Cell Surface Glycoprotein CD3 Epsilon Chain T-Cell Surface Glycoprotein CD3 ε Chain T-Cell Surface Antigen T3/Leu-4 Epsilon Chain CD3E recombinant recombinant-proteins proteins protein

 

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