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Z4P
🥰Excellent
Catalog No. T87658Cas No. 2361760-87-2
Alias Z4-P
Z4P, an IRE1 inhibitor with blood-brain barrier permeability (BBB) (IC50=1.13 μM), inhibits glioblastoma growth and recurrence in combination with Temozolomide.
Z4P
🥰Excellent
Purity: 98.99%
Catalog No. T87658Alias Z4-PCas No. 2361760-87-2
Z4P, an IRE1 inhibitor with blood-brain barrier permeability (BBB) (IC50=1.13 μM), inhibits glioblastoma growth and recurrence in combination with Temozolomide.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $74 | In Stock | |
| 5 mg | $179 | In Stock | |
| 10 mg | $297 | In Stock | |
| 25 mg | $596 | In Stock | |
| 50 mg | $953 | In Stock | |
| 100 mg | $1,480 | In Stock | |
| 200 mg | $1,980 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $198 | In Stock |
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Purity:98.99%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Z4P, an IRE1 inhibitor with blood-brain barrier permeability (BBB) (IC50=1.13 μM), inhibits glioblastoma growth and recurrence in combination with Temozolomide. |
| In vitro | Z4P inhibits IRE1α RNase activity in GBM cells (U87, RADH87, U251, UTMZ), reducing XBP1s and SPARC expression and showing dose-dependent antiproliferative effects. At 25 μM (48 h), Z4P significantly suppresses GBM cell viability and enhances the efficacy of TMZ[1]. |
| In vivo | Z4P crosses the BBB and, at 300 μg/kg i.p. daily for 28 days, significantly reduces tumor size in GBM xenograft mice. Combined with TMZ, Z4P causes near-complete tumor regression with no evident toxicity[1]. |
| Alias | Z4-P |
| Molecular Weight | 312.41 |
| Formula | C19H24N2O2 |
| Cas No. | 2361760-87-2 |
| Smiles | O=C(NC1=CC(=CC=C1C)C)NC(C)CCC2=CC=C(O)C=C2 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (256.07 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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