Shopping Cart

Your shopping cart is currently empty

Z4P

Name: Z4P
Brand: TargetMol
SKU: T87658
Price: 74 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Catalog No. T87658Cas No. 2361760-87-2

Alias Z4-P

Z4P, an IRE1 inhibitor with blood-brain barrier permeability (BBB) (IC50=1.13 μM), inhibits glioblastoma growth and recurrence in combination with Temozolomide.

Z4P

Copy Product Info

😃Good

Purity: 98.99%

Catalog No. T87658Alias Z4-PCas No. 2361760-87-2

Z4P, an IRE1 inhibitor with blood-brain barrier permeability (BBB) (IC50=1.13 μM), inhibits glioblastoma growth and recurrence in combination with Temozolomide.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$74	-	In Stock
5 mg	$179	-	In Stock
10 mg	$297	-	In Stock
25 mg	$596	-	In Stock
50 mg	$953	-	In Stock
100 mg	$1,480	-	In Stock
200 mg	$1,980	-	In Stock
1 mL x 10 mM (in DMSO)	$198	-	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:98.99%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Z4P, an IRE1 inhibitor with blood-brain barrier permeability (BBB) (IC50=1.13 μM), inhibits glioblastoma growth and recurrence in combination with Temozolomide.
In vitro	Z4P inhibits IRE1α RNase activity in GBM cells (U87, RADH87, U251, UTMZ), reducing XBP1s and SPARC expression and showing dose-dependent antiproliferative effects. At 25 μM (48 h), Z4P significantly suppresses GBM cell viability and enhances the efficacy of TMZ[1].
In vivo	Z4P crosses the BBB and, at 300 μg/kg i.p. daily for 28 days, significantly reduces tumor size in GBM xenograft mice. Combined with TMZ, Z4P causes near-complete tumor regression with no evident toxicity[1].
Synonyms	Z4-P

Chemical Properties

Molecular Weight	312.41
Formula	C₁₉H₂₄N₂O₂
Cas No.	2361760-87-2
Smiles	O=C(NC1=CC(=CC=C1C)C)NC(C)CCC2=CC=C(O)C=C2

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 80 mg/mL (256.07 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 3.3 mg/mL (10.56 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2009 mL	16.0046 mL	32.0092 mL	160.0461 mL
5 mM	0.6402 mL	3.2009 mL	6.4018 mL	32.0092 mL
10 mM	0.3201 mL	1.6005 mL	3.2009 mL	16.0046 mL
20 mM	0.1600 mL	0.8002 mL	1.6005 mL	8.0023 mL
50 mM	0.0640 mL	0.3201 mL	0.6402 mL	3.2009 mL
100 mM	0.0320 mL	0.1600 mL	0.3201 mL	1.6005 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Z4P

Z4P

Featured Recommendations