Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Anti-inflammatory agent 48 functions by inhibiting the NF-κB signaling pathway and activating HO-1 expression, characterizing its role as an anti-inflammatory agent [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | Inquiry | Inquiry | |
50 mg | Inquiry | Inquiry |
Description | Anti-inflammatory agent 48 functions by inhibiting the NF-κB signaling pathway and activating HO-1 expression, characterizing its role as an anti-inflammatory agent [1]. |
In vitro | Anti-inflammatory agent 48 (compound 1; 20 mg/kg) exhibited the capability to inhibit NO production in LPS-induced RAW 264.7 macrophages. Compared to Diclofenac, Anti-inflammatory agent 48 demonstrated superior inhibition of NF-κB by activating the Nrf2/HO-1 signaling pathway in RAW 264.7 cells [1]. |
In vivo | Anti-inflammatory agent 48 (compound 1; 20 mg/kg) significantly alleviated colitis in a dextran sulfate sodium (DSS)-induced mouse model by upregulating HO-1 and downregulating the phosphorylation levels of NF-κB p65 [1]. |
Molecular Weight | 442.33 |
Formula | C24H21Cl2NO3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Anti-inflammatory agent 48 NF-Κb NF-κB inhibitor inhibit