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CEACAM6 Protein, Human, Recombinant (His), Biotinylated

(Synonyms: NCA, CEAL, CEA, CD66c, carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)) Copy Product Info

Synonyms: NCA, CEAL, CEA, CD66c, carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)

Catalog No. TMPY-05460 Copy Product Info
CEACAM6 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 32.6 kDa and the accession number is P40199.

Product Introduction

Bioactivity
Bioactivity
Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Description
CEACAM6 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 32.6 kDa and the accession number is P40199.
Species
Human
Expression System
HEK293 Cells
TagC-His
Accession NumberP40199
ConstructionA DNA sequence encoding the human CEACAM6 (NP_002474.3) (Met1-Gly320) with a C-terminal polyhistidine tag was expressed. The purified protein was biotinylated in vitro. Predicted N terminal: Lys 35
Protein Purity
> 95 % as determined by SDS-PAGE.
Endotoxin< 1.0 EU/μg of the protein as determined by the LAL method.
FormulationLyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
ReconstitutionA Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
SynonymsNCA, CEAL, CEA, CD66c, carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
Research Background
Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6), also known as nonspecific crossreacting antigen (NCA) and CD66c, is one of seven human CEACAM family members within the immunoglobulin superfamily. It s a glycosylphosphatidylinositol-linked immunoglobulin superfamily member that is overexpressed in a variety of human cancers, including colon, breast and lung and is associated with tumourigenesis, tumour cell adhesion, invasion and metastasis. CEACAM6 is a unique mediator of migration and invasion of drug resistant oestrogen-deprived breast cancer cells, and this protein could be an important biomarker of metastasis. CEACAM6 is expressed by granulocytes and their progenitors. It is also expressed by epithelia of various organs and is upregulated in pancreatic and colon adenocarcinomas, as well as hyperplastic polyps. Resistance to adhesion-related apoptosis in tumor cells is conferred in the condition of CEACAM6 overexpression.
Chemical Properties
Molecular Weight32.6 kDa (predicted)
Storage & Solubility Information
ShippingIn general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
StorageIt is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

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Keywords

Related Tags: CEACAM6 Protein, Human, Recombinant (His), Biotinylated chemical structure | CEACAM6 Protein, Human, Recombinant (His), Biotinylated molecular weight