Powder: -20°C for 3 years | In solvent: -80°C for 1 year
hCAIX/XII-IN-5 (Coumarin 9a) is an inhibitor of carbonic anhydrase (CA) that shows excellent hCA IX/XII selectivity with Kis of 93.3 and 85.7 nM over hCA I and hCA II, respectively. hCAIX/XII-IN-5 has anti-proliferative activities to cancer cells that can delay cell cycle and induce apoptosis [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 10-14 weeks | $ 1,520.00 | |
50 mg | 10-14 weeks | $ 1,980.00 | |
100 mg | 10-14 weeks | $ 2,500.00 |
Description | hCAIX/XII-IN-5 (Coumarin 9a) is an inhibitor of carbonic anhydrase (CA) that shows excellent hCA IX/XII selectivity with Kis of 93.3 and 85.7 nM over hCA I and hCA II, respectively. hCAIX/XII-IN-5 has anti-proliferative activities to cancer cells that can delay cell cycle and induce apoptosis [1]. |
In vitro | Treatment with hCAIX/XII-IN-5 (2.36-32.17 μM) has demonstrated anti-proliferative effects on MCF-7 and PANC-1 cell lines under both normoxic and hypoxic conditions. At a specific concentration of 2.69 μM over 24 hours, this compound significantly increases the accumulation of MCF-7 cells in the Sub-G1 phase and induces arrest in the G2-M phase, indicating a halt in cell cycle progression. Furthermore, the same treatment markedly elevates the proportion of annexin V-FITC-positive apoptotic MCF-7 cells, encompassing both early and late stages of apoptosis (UR+LR), which suggests an enhancement of programmed cell death. The results from Cell Proliferation and Apoptosis Analysis clearly demonstrate the compound's potential in inhibiting cell growth and inducing apoptosis in cancerous cells, with a particular efficacy noted under varying oxygen levels, as seen in the differential IC50 values under normoxic versus hypoxic conditions for both tested cell lines. |
Molecular Weight | 291.3 |
Formula | C18H13NO3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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hCAIX/XII-IN-5 inhibitor inhibit