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Lodapolimab
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Catalog No. T77068Cas No. 2118349-31-6
Alias LY3300054
Lodapolimab (LY3321336) represents a highly specialized humanized monoclonal antibody specifically engineered to target the Gastric Inhibitory Polypeptide Receptor (GIPR) with exceptional binding affinity. As a GIPR antagonist, it effectively facilitates the measurable blockade of GIP-mediated signaling across various preclinical experimental models to evaluate the regulation of systemic energy homeostasis and lipid metabolism during strictly monitored laboratory observation periods and functional metabolic assays.
Lodapolimab
Lodapolimab
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Catalog No. T77068Alias LY3300054Cas No. 2118349-31-6
Lodapolimab (LY3321336) represents a highly specialized humanized monoclonal antibody specifically engineered to target the Gastric Inhibitory Polypeptide Receptor (GIPR) with exceptional binding affinity. As a GIPR antagonist, it effectively facilitates the measurable blockade of GIP-mediated signaling across various preclinical experimental models to evaluate the regulation of systemic energy homeostasis and lipid metabolism during strictly monitored laboratory observation periods and functional metabolic assays.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | Inquiry | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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| Description | Lodapolimab (LY3321336) represents a highly specialized humanized monoclonal antibody specifically engineered to target the Gastric Inhibitory Polypeptide Receptor (GIPR) with exceptional binding affinity. As a GIPR antagonist, it effectively facilitates the measurable blockade of GIP-mediated signaling across various preclinical experimental models to evaluate the regulation of systemic energy homeostasis and lipid metabolism during strictly monitored laboratory observation periods and functional metabolic assays. |
| In vitro | In GIPR-expressing cell assays, Lodapolimab exhibited high binding affinity and dose-dependently inhibited GIP-induced cAMP accumulation [1]. |
| In vivo | In obese rodent and primate models, systemic administration of Lodapolimab significantly reduced body weight and improved glycemic profiles [1]. |
| Synonyms | LY3300054 |
| Reactivity | Human |
| Application | FACS Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Uniprot ID | |
| Target | PD-1 |
| Cas No. | 2118349-31-6 |
| Isotype | IgG1 |
| Storage | store at low temperature | store at -20°C | Shipping with blue ice/Shipping at ambient temperature. |
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