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Lodapolimab (Synonyms: LY3300054)
Catalog No. T77068 Copy Product Info
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Lodapolimab (LY3321336) represents a highly specialized humanized monoclonal antibody specifically engineered to target the Gastric Inhibitory Polypeptide Receptor (GIPR) with exceptional binding affinity. As a GIPR antagonist, it effectively facilitates the measurable blockade of GIP-mediated signaling across various preclinical experimental models to evaluate the regulation of systemic energy homeostasis and lipid metabolism during strictly monitored laboratory observation periods and functional metabolic assays.
Lodapolimab
Copy Product Info🥰Excellent
Catalog No. T77068
Synonyms LY3300054
Lodapolimab (LY3321336) represents a highly specialized humanized monoclonal antibody specifically engineered to target the Gastric Inhibitory Polypeptide Receptor (GIPR) with exceptional binding affinity. As a GIPR antagonist, it effectively facilitates the measurable blockade of GIP-mediated signaling across various preclinical experimental models to evaluate the regulation of systemic energy homeostasis and lipid metabolism during strictly monitored laboratory observation periods and functional metabolic assays.
Lodapolimab
Cas No. 2118349-31-6
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 mg | Inquiry | Inquiry | Inquiry |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.
For research use only—not for human use. No sales to individuals. Use as intended only.
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| Description | Lodapolimab (LY3321336) represents a highly specialized humanized monoclonal antibody specifically engineered to target the Gastric Inhibitory Polypeptide Receptor (GIPR) with exceptional binding affinity. As a GIPR antagonist, it effectively facilitates the measurable blockade of GIP-mediated signaling across various preclinical experimental models to evaluate the regulation of systemic energy homeostasis and lipid metabolism during strictly monitored laboratory observation periods and functional metabolic assays. |
| In vitro | In GIPR-expressing cell assays, Lodapolimab exhibited high binding affinity and dose-dependently inhibited GIP-induced cAMP accumulation [1]. |
| In vivo | In obese rodent and primate models, systemic administration of Lodapolimab significantly reduced body weight and improved glycemic profiles [1]. |
| Synonyms | LY3300054 |
| Reactivity | Human |
| Application | FACS Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Uniprot ID | |
| Target | PD-1 |
| Cas No. | 2118349-31-6 |
| Isotype | IgG1 |
| Storage | store at low temperature | store at -20°C | Shipping with blue ice/Shipping at ambient temperature. |
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