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MMAF-OtBu

Name: MMAF-OtBu
Brand: TargetMol
SKU: T84717
Price: 349 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T84717Cas No. 745017-95-2

MMAF-OtBu (Example 2) is an OtBu-modified MMAF for synthesising ADCs (antibody-drug conjugates). MMAF is an antitumour microtubule polymerisation inhibitor commonly employed as the cytotoxic component in ADCs.

MMAF-OtBu

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Purity: 98.94%

Catalog No. T84717Cas No. 745017-95-2

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$45	-	In Stock
5 mg	$106	-	In Stock
10 mg	$172	-	In Stock
25 mg	$349	-	In Stock
50 mg	Preferential	-	In Stock
1 mL x 10 mM (in DMSO)	$148	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:98.94%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description

Chemical Properties

Molecular Weight	788.07
Formula	C₄₃H₇₃N₅O₈
Cas No.	745017-95-2
Smiles	[C@H]([C@H](C(N[C@@H](CC1=CC=CC=C1)C(OC(C)(C)C)=O)=O)C)(OC)[C@]2(N(C(C[C@H]([C@@H](N(C([C@@H](NC([C@H](C(C)C)NC)=O)C(C)C)=O)C)[C@H](CC)C)OC)=O)CCC2)[H]
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (50.76 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.2689 mL	6.3446 mL	12.6892 mL	63.4461 mL
5 mM	0.2538 mL	1.2689 mL	2.5378 mL	12.6892 mL
10 mM	0.1269 mL	0.6345 mL	1.2689 mL	6.3446 mL
20 mM	0.0634 mL	0.3172 mL	0.6345 mL	3.1723 mL
50 mM	0.0254 mL	0.1269 mL	0.2538 mL	1.2689 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline /PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc