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PW0464

🥰Excellent
Catalog No. T36946Cas No. 1643462-93-4
Alias PW 0464, (Rac)-Razpipadon

PW0464 ((Rac)-Razpipadon) is a non-catechol D1R agonist and potent omplete G protein biased ligand with an EC50 (Gs-cAMP)=5.8 nM for the study of neurological disorders.

PW0464

PW0464

🥰Excellent
Purity: 98.78%
Catalog No. T36946Alias PW 0464, (Rac)-RazpipadonCas No. 1643462-93-4
PW0464 ((Rac)-Razpipadon) is a non-catechol D1R agonist and potent omplete G protein biased ligand with an EC50 (Gs-cAMP)=5.8 nM for the study of neurological disorders.
Pack SizePriceAvailabilityQuantity
1 mg$166 In Stock
5 mg$416 In Stock
10 mg$695 In Stock
25 mg$1,330 In Stock
50 mg$1,980 In Stock
1 mL x 10 mM (in DMSO)$458 In Stock
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Purity:98.78%
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Product Introduction

Bioactivity
Description
PW0464 ((Rac)-Razpipadon) is a non-catechol D1R agonist and potent omplete G protein biased ligand with an EC50 (Gs-cAMP)=5.8 nM for the study of neurological disorders.
Targets&IC50
cAMP assay (HEK293T cells):5.8 nM (EC₅₀)
In vitro
PW0464 is a non-catechol selective dopamine D1/D5 receptor agonist. In HEK293T cells overexpressing D1R or D5R, PW0464 activates G-protein signaling (cAMP production) with an EC₅₀ of 5.8 nM, indicating high potency[1].
AliasPW 0464, (Rac)-Razpipadon
Chemical Properties
Molecular Weight389.35
FormulaC19H17F2N3O4
Cas No.1643462-93-4
SmilesO=C1NC(=O)N(C(C=2C=CC(OC3=NC=CC=C3OC(F)F)=CC2C)=C1C)C
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice./Shipping at ambient temperature.
Solubility Information
DMSO: 18 mg/mL (46.23 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.5684 mL12.8419 mL25.6838 mL128.4192 mL
5 mM0.5137 mL2.5684 mL5.1368 mL25.6838 mL
10 mM0.2568 mL1.2842 mL2.5684 mL12.8419 mL
20 mM0.1284 mL0.6421 mL1.2842 mL6.4210 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
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