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PW0464

Name: PW0464
Brand: TargetMol
SKU: T36946
Price: 158 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T36946Cas No. 1643462-93-4

Alias PW 0464, (Rac)-Razpipadon

PW0464 ((Rac)-Razpipadon) is a non-catechol D1R agonist and potent omplete G protein biased ligand with an EC50 (Gs-cAMP)=5.8 nM for the study of neurological disorders.

PW0464

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Purity: 98.78%

Catalog No. T36946Alias PW 0464, (Rac)-RazpipadonCas No. 1643462-93-4

PW0464 ((Rac)-Razpipadon) is a non-catechol D1R agonist and potent omplete G protein biased ligand with an EC50 (Gs-cAMP)=5.8 nM for the study of neurological disorders.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$158	-	In Stock
5 mg	$396	-	In Stock
10 mg	$662	-	In Stock
25 mg	$1,280	-	In Stock
50 mg	$1,980	-	In Stock
100 mg	$2,660	-	In Stock
1 mL x 10 mM (in DMSO)	$436	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.78%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	PW0464 ((Rac)-Razpipadon) is a non-catechol D1R agonist and potent omplete G protein biased ligand with an EC50 (Gs-cAMP)=5.8 nM for the study of neurological disorders.
Targets&IC50	cAMP assay (HEK293T cells):5.8 nM (EC₅₀)
In vitro	PW0464 is a non-catechol selective dopamine D1/D5 receptor agonist. In HEK293T cells overexpressing D1R or D5R, PW0464 activates G-protein signaling (cAMP production) with an EC₅₀ of 5.8 nM, indicating high potency[1].
Synonyms	PW 0464, (Rac)-Razpipadon

Chemical Properties

Molecular Weight	389.35
Formula	C₁₉H₁₇F₂N₃O₄
Cas No.	1643462-93-4
Smiles	O=C1NC(=O)N(C(C=2C=CC(OC3=NC=CC=C3OC(F)F)=CC2C)=C1C)C

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 18 mg/mL (46.23 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 1.5 mg/mL (3.85 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5684 mL	12.8419 mL	25.6838 mL	128.4192 mL
5 mM	0.5137 mL	2.5684 mL	5.1368 mL	25.6838 mL
10 mM	0.2568 mL	1.2842 mL	2.5684 mL	12.8419 mL
20 mM	0.1284 mL	0.6421 mL	1.2842 mL	6.4210 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc