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PW0464

Name: PW0464
Brand: TargetMol
SKU: T36946
Price: 158 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T36946Cas No. 1643462-93-4

Alias PW 0464, (Rac)-Razpipadon

PW0464 ((Rac)-Razpipadon) is a non-catechol D1R agonist and potent omplete G protein biased ligand with an EC50 (Gs-cAMP)=5.8 nM for the study of neurological disorders.

PW0464

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Purity: 98.78%

Catalog No. T36946Alias PW 0464, (Rac)-RazpipadonCas No. 1643462-93-4

PW0464 ((Rac)-Razpipadon) is a non-catechol D1R agonist and potent omplete G protein biased ligand with an EC50 (Gs-cAMP)=5.8 nM for the study of neurological disorders.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$158	-	In Stock
5 mg	$396	-	In Stock
10 mg	$662	-	In Stock
25 mg	$1,280	-	In Stock
50 mg	$1,980	-	In Stock
100 mg	$2,660	-	In Stock
1 mL x 10 mM (in DMSO)	$436	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.78%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	PW0464 ((Rac)-Razpipadon) is a non-catechol D1R agonist and potent omplete G protein biased ligand with an EC50 (Gs-cAMP)=5.8 nM for the study of neurological disorders.
Targets&IC50	cAMP assay (HEK293T cells):5.8 nM (EC₅₀)
In vitro	PW0464 is a non-catechol selective dopamine D1/D5 receptor agonist. In HEK293T cells overexpressing D1R or D5R, PW0464 activates G-protein signaling (cAMP production) with an EC₅₀ of 5.8 nM, indicating high potency[1].
Synonyms	PW 0464, (Rac)-Razpipadon

Chemical Properties

Molecular Weight	389.35
Formula	C₁₉H₁₇F₂N₃O₄
Cas No.	1643462-93-4
Smiles	O=C1NC(=O)N(C(C=2C=CC(OC3=NC=CC=C3OC(F)F)=CC2C)=C1C)C

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 18 mg/mL (46.23 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 1.5 mg/mL (3.85 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5684 mL	12.8419 mL	25.6838 mL	128.4192 mL
5 mM	0.5137 mL	2.5684 mL	5.1368 mL	25.6838 mL
10 mM	0.2568 mL	1.2842 mL	2.5684 mL	12.8419 mL
20 mM	0.1284 mL	0.6421 mL	1.2842 mL	6.4210 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc