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Ligand for Target Protein for PROTAC

FilterHomePROTACLigand for Target Protein for PROTAC
  • (+)-JQ-1
    T21101268524-70-4
    (+)-JQ-1 (JQ1) is a BET bromine domain inhibitor that inhibits BRD4 (1/2) (IC50=77/33 nM) with specificity and reversibility. (+)-JQ-1 induces cell autophagy and inhibits cell proliferation.
    • $30
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  • Quizartinib
    T2066950769-58-1
    Quizartinib (AC220) is an inhibitor of FLT3 (Kd: 1.6 nM) and demonstrates high selectivity for FLT3 when tested against a panel of 227 additional kinases.
    • $53
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  • Ibrutinib
    T1835936563-96-1
    Ibrutinib (PCI-32765) is an irreversible inhibitor of BTK (IC50: 0.5 nM) that selectively blocks B cell activation.
    • $36
    In Stock
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    TargetMol | Citations Cited
  • SMARCA-BD ligand 1 for Protac
    T138481997319-92-2In house
    SMARCA-BD ligand 1 for Protac is a compound capable of binding to SMARCA2, the BAF ATPase subunit, based on the Protac technology for degrading SMARCA2
    • $197
    In Stock
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  • AP1867-3-(aminoethoxy)
    T135492127390-15-0In house
    AP1867-3-(aminoethoxy) is a synthetic ligand for FKBP and can be used in the synthesis of PROTAC FKBP12 F36V degrader.
      7-10 days
      Inquiry
      TargetMol | Inhibitor Sale
    • Androgen receptor antagonist 1
      T103201338812-36-4In house
      Androgen receptor antagonist 1 is an orally available full androgen receptor antagonist (IC50: 59 nM). It can be used in the synthesis of PROTAC AR degraders, which results in 24% and 47 % AR protein degradation in LNCaP cells at 1 μM and 10 μM, respectively.
      • $1,520
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      QTY
    • PROTAC BRD4 ligand-1
      T125512313230-51-0In house
      PROTAC BRD4 ligand-1 is a ligand for PROTAC GNE-987 targeting the BRD4 protein and is an inhibitor of BET.
      • $125
      In Stock
      Size
      QTY
    • CDK ligand for PROTAC hydrochloride
      T10734L
      CDK ligand for PROTAC hydrochloride is a CDK inhibitor with antitumor activity. It has been used to design PROTAC CDK4/6 degraders.
      • $311
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    • Ipatasertib-NH2
      T180531001382-14-4
      Ipatasertib-NH2 (GDC-0068-NH2;RG7440-NH2) is a ligand for target protein AKT for PROTAC, binds to lenalidomide, a ligand of ubiquitin E3 ligase cereblon (CRBN), via a ten-hydrocarbon linker to form INY-03-041 to degrade AKT[1].
      • Inquiry Price
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    • SirReal1-O-propargyl
      T186411862237-99-7
      SirReal1-O-propargyl, a moiety based on SirReal1, is a selective and highly potent inhibitor of Sirtuin 2 (Sirt2), demonstrating an IC50 of 2.4 μM. It operates by binding to the cereblon ligand through a linker, facilitating the formation of PROTAC for the degradation of Sirt2[1].
      • Inquiry Price
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    • AP1867-2-(carboxymethoxy)
      T186112230613-03-1
      AP1867-2-(carboxymethoxy), a moiety based on the synthetic FKBP12F36V-directed ligand AP1867, connects to the CRBN ligand through a linker to generate dTAG molecules[1].
      • $284
      5 days
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    • SI-109
      T12905
      SI-109 is a potent inhibitor of STAT3 SH2 domain (Ki=9 nM),and with antitumor activity.
      • Inquiry Price
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    • Palbociclib-propargyl
      T185152366269-23-8
      Palbociclib-propargyl, a PROTAC ligand targeting the protein CDK6, connects to the CRBN ligand through a PEG linker to form PROTAC CP-10. CP-10 exhibits a potent DC50 value of 2.1 nM against CDK6[1].
      • $83
      5 days
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      QTY
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    • Desmethyl-QCA276
      T186012126819-55-2
      Desmethyl-QCA276, the QCA276-based moiety, binds to cereblon ligand via a linker to form PROTAC to degrade BET. QCA276 is a BET inhibitor with an IC50 of 10 nM, and with a Ki of 2.3 nM[1].
      • Inquiry Price
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    • PROTAC Her3-binding moiety 1
      T138411603845-36-8
      PROTAC Her3-binding moiety 1 is a Her3 Ligand for PROTAC.
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    • Imatinib carbaldehyde
      T185921436868-85-7
      Imatinib carbaldehyde (also known as CGP-57148B carbaldehyde) is a compound derived from Imatinib, an inhibitor of the ABL protein. Imatinib carbaldehyde binds to the IAP ligand with the assistance of a linker, resulting in the formation of SNIPER[1].
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    • CDK9-IN-11
      T107432748368-15-0
      CDK9-IN-11 is a potent CDK9 inhibitor that is the ligand for the PROTAC CDK9 Degrader-1 [1].
      • $1,520
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    • BET-IN-6
      T105222570470-39-0
      BET-IN-6, a ligand with potent and high affinity for inhibiting BRD2/BRD4, plays a crucial role in the synthesis of PROTAC BRD2/BRD4 degrader-1 [1], targeting the protein BRD2/4.
      • $1,520
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    • PROTAC BRD9-binding moiety 1 hydrochloride
      T13915L
      PROTAC BRD9-binding moiety 1 hydrochloride binds to BRD9, and used for inhibiting BRD9 activity, based on PROTAC.
      • $373
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    • GNF5-amido-Me
      T18593778277-37-5
      GNF5-amido-Me, the moiety based on GNF5 (ABL inhibitor),binds through a linker to the IAP ligand forming SNIPER[1].
      • Inquiry Price
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    • FN-1501-propionic acid
      T136962408642-48-6
      FN-1501-propionic acid, a CDK2/9 ligand, in conjunction with a CRBN ligand, has been utilized in the design of a PROTAC CDK2/9 degrader.
      • $1,520
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    • Apcin-A
      T103451683617-62-0
      Apcin-A is an anaphase-promoting complex (APC) inhibitor. It interacts strongly with Cdc20 and inhibits the ubiquitination of Cdc20 substrates. Apcin-A can be used to synthesize the PROTAC CP5V.
      • $169
      5 days
      Size
      QTY
    • Ch55-O-C3-NH2
      T18650144298-98-6
      Ch55-O-C3-NH2, also known as RAR ligand 1, is a ligand derived from the Ch55 compound that specifically targets RAR. Through a linker, Ch55-O-C3-NH2 interacts with cIAP1 ligand Bestatin to form SNIPER[1].
      • Inquiry Price
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    • Estrone-N-O-C1-amido
      T17940138219-84-8
      Estrone-N-O-C1-amido (ERα ligand 1) is an estrogen ligand derived from Estrone that specifically binds to estrogen receptor α (ERα). Through a linker, Estrone-N-O-C1-amido (ERα ligand 1) forms a complex with the cIAP1 ligand Bestatin, leading to the creation of SNIPER[1].
      • Inquiry Price
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    • I-BET762 carboxylic acid
      T130861300019-38-8
      I-BET762 carboxylic acid is an inhibitor of BRD4(pIC50 of 5.1).
      • $48
      5 days
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      QTY
    • A-1210477-piperazinyl
      T191722351218-72-7
      A-1210477-piperazinyl is a compound that specifically targets and binds to the protein myeloid cell leukemia 1 (MCL1). This compound is utilized in PROTAC technology, which harnesses the ability to selectively degrade target proteins.
      • Inquiry Price
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    • CDK ligand for PROTAC
      T10734
      CDK ligand for PROTAC is a CDK inhibitor with antitumor activity. It has been used to design PROTAC CDK4/6 degraders.
      • Inquiry Price
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    • CCR7 Ligand 1
      T10716681514-83-0
      CCR7 Ligand 1 (CCR7-Cmp2105) is an allosteric Ligand and antagonist for human CC chemokine receptor 7 (CCR7) with a Kd of 3 nM. CCR7 Ligand 1, thiadiazole-dioxide ligan, suppresses arrestin binding in response to activation by CCL19 with an IC50 of 7.3 μM
      • $1,870
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    • HG-7-85-01-Decyclopropane
      T18594
      Decyclopropane, also known as HG-7-85-01, is a chemical compound with ABL inhibitor properties. It binds to the IAP ligand through a linker, resulting in the formation of SNIPER [1].
      • Inquiry Price
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    • BI-4464
      T54801227948-02-8
      BI-4464 is a highly selective ATP competitive inhibitor of PTK2/FAK, with an IC50 of 17 nM. A PTK2 ligand for PROTAC
      • $52
      In Stock
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    • PROTAC BET-binding moiety 2
      T12558916493-82-8
      PROTAC BET-binding moiety 2 is an BET bromodomain inhibitor.
        7-10 days
        Inquiry
      • DUPA
        T19301302941-52-2
        DUPA (N,N''-Carbonylbis[L-glutamic acid]) is used as the targeting moiety to actively deliver DTX for treatment of Prostate-Specific Membrane Antigen (PSMA) expressing prostate cancer.
        • $37
        In Stock
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      • SLF-amido-C2-COOH
        T139141092369-24-8
        SLF-amido-C2-COOH is a synthetic ligand for FKBP (SLF), and can be used in the synthesis of PROTACs.
        • $131
        5 days
        Size
        QTY
      • Dasatinib carbaldehyde
        T185952112837-79-1
        Dasatinib carbaldehyde (PROTAC ABL binding moiety 4) is based on Dasatinib which is an ABL inhibitor, binds to the IAP ligand via a linker, and forms SNIPER [1].
        • $48
        In Stock
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      • ATRA-hydroxyimino
        T17733135325-47-2
        ATRA-hydroxyimino, also known as CRABP-II ligand 1, is a chemical compound derived from Retinoic acid (ATRA). This compound binds to the cIAP1 ligand, specifically Bestatin, through a linker, resulting in the formation of a complex called SNIPER. The purpose of this complex is to degrade CRABP-II within IMR-32 cells[1].
        • Inquiry Price
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      • MAK683-CH2CH2COOH
        T137652639882-68-9
        MAK683-CH2CH2COOH binds to EED (embryonic ectoderm development protein). MAK683-CH2CH2COOH and a VHL ligand for the E3 ubiquitin ligase have been used to design EED-Targeted PROTAC which are EED degrader-1 and PROTAC EED degrader-2 [1].
        • $1,517
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      • EED226-COOH
        T17931
        EED226-COOH, derived from EED226, serves as a ligand targeting the EED protein for PROTAC applications. It attaches to a VHL ligand through a linker, culminating in the formation of UNC6852, which specifically degrades PRC2[1].
        • $183
        5 days
        Size
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      • Androstanolone acetate
        T142881164-91-6
        Androstanolone acetate is a compound that functions as an androgen ligand, specifically targeting the androgen receptor (AR). It binds to the cIAP1 ligand Bestatin through a linker, resulting in the formation of PROTACs[1].
          Inquiry
        • Navitoclax-piperazine
          T121862143096-93-7
          Navitoclax-piperazine (ABT-263-piperazine) is an inhibitor of B-cell lymphoma extra large (BCL-XL).
          • $158
          In Stock
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        • PROTAC IRAK4 ligand-1
          T138432357108-39-3
          PROTAC IRAK4 ligand-1 is a synthetic ligand for interleukin-1 receptor-associated kinase 4.
            7-10 days
            Inquiry
          • SLF
            T13888195513-96-3
            SLF is a synthetic ligand for FK506-binding protein (FKBP)( with an affinity of 3.1 μM for FKBP51 and an IC50 of 0.22 μM for FKBP12). SLF can be used in the synthesis of PROTAC.
            • $77
            5 days
            Size
            QTY
          • PROTAC BET-binding moiety 1
            T125572093387-77-8
            PROTAC BET-binding moiety 1 is a key intermediate in the synthesis of high affinity BET inhibitors
              7-10 days
              Inquiry
            • PROTAC BRD9-binding moiety 1
              T139152097512-23-5
              PROTAC BRD9-binding moiety 1 that binds to BRD9, and used for inhibiting BRD9 activity, based on PROTAC.
              • Inquiry Price
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            • PROTAC BRD4-binding moiety 1
              T185992101200-10-4
              PROTAC BRD4-binding moiety 1 is a BRD4 ligand that binds to the cereblon ligand through a linker, enabling the formation of a PROTAC complex. This complex efficiently degrades BRD4[1].
              • Inquiry Price
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            • N-Deshydroxyethyl Dasatinib
              T18750910297-51-7
              N-Deshydroxyethyl Dasatinib (N-Deshydroxyethyl BMS-354825) is a metabolite of Dasatinib, a dasatinib-based molecule that degrades ABL by binding to the IAP ligand via a linker to form SNIPER.N-Deshydroxyethyl Dasatinib is used in the study of cancer and immune diseases.
              • $84
              In Stock
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