Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Caspase-3 activator 3 (compound 2h) effectively induces apoptosis in HL-60 and K562 cells by substantially activating caspase-3, demonstrating antileukemic activity with IC50 values of 42.89 μM and 33.61 μM, respectively [1].
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Description | Caspase-3 activator 3 (compound 2h) effectively induces apoptosis in HL-60 and K562 cells by substantially activating caspase-3, demonstrating antileukemic activity with IC50 values of 42.89 μM and 33.61 μM, respectively [1]. |
In vitro | BX-2819 (0.001-10 μM, 16 h) inhibits the expression of ErbB2 protein and significantly enhances the expression of Hsp70 in HT-29, OVCAR3, and SKBR3 cells [1]. |
In vivo | BX-2819 administered at 100 mg/kg intraperitoneally (i.p.) twice weekly substantially inhibited the expression of ErbB2 protein in NCI-N87 and SKOV3 tumor-bearing mice. Additionally, in HT-29 and NCI-N87 tumor models, it significantly reduced tumor growth and overall tumor burden [1]. A single dose of BX-2819 at 2 mg/kg given intravenously (i.v.) demonstrated a relatively short serum half-life (t1/2 = 0.8 h), high clearance (CL = 159 mL/min/kg), and a large volume of distribution (Vss = 4.5 L) in mice [1]. |
Molecular Weight | N/A |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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Caspase-3 activator 3 Apoptosis Proteases/Proteasome Caspase inhibitor inhibit