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Caspase-3 activator 3
Caspase-3 activator 3
Caspase-3 activator 3 (compound 2h) effectively induces apoptosis in HL-60 and K562 cells by substantially activating caspase-3, demonstrating antileukemic activity with IC50 values of 42.89 μM and 33.61 μM, respectively [1].
Catalog No. T82774
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Caspase-3 activator 3
Catalog No. T82774
Caspase-3 activator 3 (compound 2h) effectively induces apoptosis in HL-60 and K562 cells by substantially activating caspase-3, demonstrating antileukemic activity with IC50 values of 42.89 μM and 33.61 μM, respectively [1].
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | Inquiry | Backorder | |
| 50 mg | Inquiry | Backorder |
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Product Introduction
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| Description | Caspase-3 activator 3 (compound 2h) effectively induces apoptosis in HL-60 and K562 cells by substantially activating caspase-3, demonstrating antileukemic activity with IC50 values of 42.89 μM and 33.61 μM, respectively [1]. |
| In vitro | BX-2819 (0.001-10 μM, 16 h) inhibits the expression of ErbB2 protein and significantly enhances the expression of Hsp70 in HT-29, OVCAR3, and SKBR3 cells [1]. |
| In vivo | BX-2819 administered at 100 mg/kg intraperitoneally (i.p.) twice weekly substantially inhibited the expression of ErbB2 protein in NCI-N87 and SKOV3 tumor-bearing mice. Additionally, in HT-29 and NCI-N87 tumor models, it significantly reduced tumor growth and overall tumor burden [1]. A single dose of BX-2819 at 2 mg/kg given intravenously (i.v.) demonstrated a relatively short serum half-life (t1/2 = 0.8 h), high clearance (CL = 159 mL/min/kg), and a large volume of distribution (Vss = 4.5 L) in mice [1]. |
| Cas No. |
| Storage | Shipping with blue ice. |
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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