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Anti-PYCARD Polyclonal Antibody
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Catalog No. TMAB-01595
Alias TMS1, Target of methylation-induced silencing 1, PYD and CARD domain-containing protein, PYCARD, hASC, Caspase recruitment domain-containing protein 5, CARD5, ASC, Apoptosis-associated speck-like protein containing a CARD
Anti-PYCARD Polyclonal Antibody is a Rabbit antibody targeting PYCARD. Anti-PYCARD Polyclonal Antibody can be used in WB.
Anti-PYCARD Polyclonal Antibody
Anti-PYCARD Polyclonal Antibody
😃Good
Catalog No. TMAB-01595Alias TMS1, Target of methylation-induced silencing 1, PYD and CARD domain-containing protein, PYCARD, hASC, Caspase recruitment domain-containing protein 5, CARD5, ASC, Apoptosis-associated speck-like protein containing a CARD
Anti-PYCARD Polyclonal Antibody is a Rabbit antibody targeting PYCARD. Anti-PYCARD Polyclonal Antibody can be used in WB.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $222 | 7-10 days | |
| 100 μL | $372 | 7-10 days |
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-PYCARD Polyclonal Antibody is a Rabbit antibody targeting PYCARD. Anti-PYCARD Polyclonal Antibody can be used in WB. |
| Alias | TMS1, Target of methylation-induced silencing 1, PYD and CARD domain-containing protein, PYCARD, hASC, Caspase recruitment domain-containing protein 5, CARD5, ASC, Apoptosis-associated speck-like protein containing a CARD |
| Ig Type | IgG |
| Reactivity | Human |
| Verified Activity | Sample: Lane 1: Spleen (Rat) Lysate at 40 μg Lane 2: U937 (Human) Cell Lysate at 30 μg Lane 3: THP-1 (Human) Cell Lysate at 30 μg Primary: Anti-ASC (TMAB-01595) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 26 kDa Observed band size: 24 kDa |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cytoplasm. Note=Upstream of caspase activation, a redistribution from the cytoplasm to the aggregates occurs. These appear as hollow, perinuclear spherical, ball-like structures. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Research Background | Promotes caspase-mediated apoptosis. This proapoptotic activity is mediated predominantly through the activation of caspase-9. May be a component of the inflammasome, a protein complex which also includes NALP2, CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases. Tissue specificity: Widely expressed at low levels. Detected in peripheral blood leukocytes, lung, small intestine, spleen, thymus, colon and at lower levels in placenta, liver and kidney. Very low expression in skeletal muscle, heart and brain. Detected in the leukemia cell lines HL-60 and U937, but not in Jurkat T-cell lymphoma and Daudi Burkitt's lymphoma. |
| Immunogen | Recombinant Protein: human ASC |
| Antigen Species | Human |
| Gene ID | |
| Uniprot ID | |
| Biology Area | Tumor biomarkers,Associated Proteins,CARD Family |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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