Powder: -20°C for 3 years | In solvent: -80°C for 1 year
2-(Cyclohexylmethyl)-Plumbagin, a naphthoquinone derivative, exhibits selective cytotoxicity towards PANC-1 human pancreatic cancer cells under nutrient-deprived conditions—a situation akin to the pancreatic cancer tumor microenvironment—over those in nutrient-rich settings, with PC50 values of 0.11 and 47.2 µM, respectively. At a 1 µM concentration, it triggers apoptosis in PANC-1 cells. Furthermore, this compound specifically inhibits the phosphorylation of Akt and mammalian target of rapamycin (mTOR) in PANC-1 cells under nutrient scarcity. In a MiaPaCa-2 pancreatic cancer mouse xenograft model, it significantly reduces tumor volume and weight when administered at 50 and 250 µg/animal dosages five times weekly.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | 35 days | $ 65.00 | |
5 mg | 35 days | $ 290.00 | |
10 mg | 35 days | $ 497.00 |
Description | 2-(Cyclohexylmethyl)-Plumbagin, a naphthoquinone derivative, exhibits selective cytotoxicity towards PANC-1 human pancreatic cancer cells under nutrient-deprived conditions—a situation akin to the pancreatic cancer tumor microenvironment—over those in nutrient-rich settings, with PC50 values of 0.11 and 47.2 µM, respectively. At a 1 µM concentration, it triggers apoptosis in PANC-1 cells. Furthermore, this compound specifically inhibits the phosphorylation of Akt and mammalian target of rapamycin (mTOR) in PANC-1 cells under nutrient scarcity. In a MiaPaCa-2 pancreatic cancer mouse xenograft model, it significantly reduces tumor volume and weight when administered at 50 and 250 µg/animal dosages five times weekly. |
Molecular Weight | 270.30 |
Formula | C17H18O3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: Slightly soluble
DMSO: Slightly soluble
DMF: 1 mg/ml
You can also refer to dose conversion for different animals. More
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2-(cyclohexylmethyl)-Plumbagin inhibitor inhibit