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BJJF078

Catalog No. T67865 CAS 2531244-56-9

BJJF078, an aminopiperidine derivative, is a potent inhibitor of recombinant human and mouse glutamine aminotransferase (TG2) activity, with IC50 values of 41 and 54 nM for human and mouse glutamine aminotransferase, respectively.BJJF078 inhibits TG1 enzyme, with an IC50 of 0.16 μM.BJJF078 can be used to study multiple sclerosis (MS). BJJF078 can be used to study multiple sclerosis (MS).

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BJJF078, CAS 2531244-56-9

Pack Size	Availability	Price/USD
1 mg	In stock	$ 53.00
5 mg	In stock	$ 111.00
10 mg	In stock	$ 159.00
25 mg	In stock	$ 266.00
50 mg	In stock	$ 396.00
100 mg	In stock	$ 589.00

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Purity: 98.19%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	BJJF078, an aminopiperidine derivative, is a potent inhibitor of recombinant human and mouse glutamine aminotransferase (TG2) activity, with IC50 values of 41 and 54 nM for human and mouse glutamine aminotransferase, respectively.BJJF078 inhibits TG1 enzyme, with an IC50 of 0.16 μM.BJJF078 can be used to study multiple sclerosis (MS). BJJF078 can be used to study multiple sclerosis (MS).
Targets&IC50	TGase 1:0.16 μM, TG2 (human):41 nM, TG2 (mouse):54 nM

Molecular Weight	523.6
Formula	C27H29N3O6S
CAS No.	2531244-56-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/mL (114.59 mM)

References and Literature

1. Chrobok NL, et al. Characterization of Transglutaminase 2 activity inhibitors in monocytes in vitro and their effect in a mouse model for multiple sclerosis [published correction appears in PLoS One. 2018 Dec 13;13(12):e0209522]. PLoS One. 2018;13(4):e019643

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Bioactive Compound Library Bioactive Compounds Library Max

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

BJJF078 2531244-56-9 Proteases/Proteasome Glutaminase BJJF 078 BJJF-078 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.