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AMPA receptor modulator-4

Catalog No. T78971 CAS 2917551-59-6

AMPA Receptor Modulator-4, a 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide (BTD), serves as an orally active positive allosteric modulator of the AMPA receptors (AMPAR PAMs). This compound is capable of crossing the blood-brain barrier and has been found to enhance cognitive performance and working memory in mice [1].

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AMPA receptor modulator-4 Chemical Structure

AMPA receptor modulator-4, CAS 2917551-59-6

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 1,520.00
50 mg	6-8 weeks	$ 1,980.00
100 mg	6-8 weeks	$ 2,500.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

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Description	AMPA Receptor Modulator-4, a 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide (BTD), serves as an orally active positive allosteric modulator of the AMPA receptors (AMPAR PAMs). This compound is capable of crossing the blood-brain barrier and has been found to enhance cognitive performance and working memory in mice [1].
In vitro	AMPA receptor modulator-4 (compound 15e) exhibits a pEC50 value of 5.66 for the calcium influx induced by 1 mM glutamate in HEK293 cells stably expressing the GluA2(Q) subunit [1]. The effective concentration of AMPA receptor modulator-4 required to double the response (EC2x) is 2.1 μM in FlipR and 1.5 μM in FDSS assays [1].
In vivo	AMPA receptor modulator-4 administered intraperitoneally at a dose of 10 mg/kg increased the duration of Long-Term Potentiation (LTP) in rats [1]. Oral administration of the compound at 1 and 3 mg/kg, one hour prior to three treatment sessions, significantly enhanced cognitive abilities in CD1 mice [1]. The modulator, given via intraperitoneal injection at 0.03, 0.1, and 0.3 mg/kg, improved spontaneous alternation behavior and working memory performance in C57BL/6 mice [1]. Additionally, AMPA receptor modulator-4, at 30 and 100 mg/kg orally, exhibited anticonvulsant effects in NMRI mice [1].

Molecular Weight	290.74
Formula	C11H12ClFN2O2S
CAS No.	2917551-59-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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Keywords

AMPA receptor modulator-4 2917551-59-6 Membrane transporter/Ion channel Neuroscience iGluR inhibitor inhibit

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