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iHCK-37

Name: iHCK-37
Brand: TargetMol
SKU: T40594
Price: 126 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T40594Cas No. 516478-09-4

Alias ASN05260065, ASN 05260065

iHCK-37 (ASN05260065) is a selective Hck inhibitor with antitumor activity, blocking HIV-1 viral replication. iHCK-37 reduces PI3K/AKT and MAPK/ERK pathway activation after erythropoietin induction in high Hck-expressing cells, useful in chronic myelogenous leukemia (CML) research.

iHCK-37

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Purity: 99.97%

Catalog No. T40594Alias ASN05260065, ASN 05260065Cas No. 516478-09-4

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$126	In Stock	In Stock
5 mg	$313	In Stock	In Stock
10 mg	$496	In Stock	In Stock
25 mg	$953	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$345	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.97%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	iHCK-37 (ASN05260065) is a selective Hck inhibitor with antitumor activity, blocking HIV-1 viral replication. iHCK-37 reduces PI3K/AKT and MAPK/ERK pathway activation after erythropoietin induction in high Hck-expressing cells, useful in chronic myelogenous leukemia (CML) research.
Targets&IC50	Hck:0.22 μM (Ki)
In vitro	Methods: AML cell lines (HL60, KG1a and U937) and chronic myeloid leukemia cell lines (HEL and K562) were treated with iHCK-37 (5.0-20 μM, 24 hours) and cell viability was detected. Results: iHCK-37 showed effective antiproliferative activity in vitro, with growth inhibition (GI50) of 5.0-5.8 μM for AML cell lines (HL60, KG1a and U937) and 9.1-19.2 μM for chronic myeloid leukemia cell lines (HEL and K562). [2] Methods: Lentivirus HCK-silenced K562 and U937 cell lines and KG1a (AML/CD34+) cell lines were treated with iHCK-37 (3-9 μM) and protein level changes were detected by WB. Results: iHCK-37 led to decreased phosphorylation of ERK, AKT, and P70S6K in lentiviral HCK-silenced K562 and U937 cell lines; and decreased p-HCK, p-ERK, p-AKT, and p-70S6 in the KG1a (AML/CD34+) cell line in a concentration-dependent manner. [2]
Synonyms	ASN05260065, ASN 05260065

Chemical Properties

Molecular Weight	544.73
Formula	C₃₀H₃₂N₄O₂S₂
Cas No.	516478-09-4
Smiles	O=C(NC=1C=CC=CC1N2CCOCC2)CSC=3N=C(N=C4SC5=C(C43)CCCC5)CCC=6C=CC=CC6
Relative Density.	1.34 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 200 mg/mL (367.15 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8358 mL	9.1789 mL	18.3577 mL	91.7886 mL
5 mM	0.3672 mL	1.8358 mL	3.6715 mL	18.3577 mL
10 mM	0.1836 mL	0.9179 mL	1.8358 mL	9.1789 mL
20 mM	0.0918 mL	0.4589 mL	0.9179 mL	4.5894 mL
50 mM	0.0367 mL	0.1836 mL	0.3672 mL	1.8358 mL
100 mM	0.0184 mL	0.0918 mL	0.1836 mL	0.9179 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc