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Z-Ala-Ala-Asp-CMK

Name: Z-Ala-Ala-Asp-CMK
Brand: TargetMol
SKU: T80745
Price: 123 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T80745Cas No. 183284-21-1

Alias Z-AAD-CMK

Z-Ala-Ala-Asp-CMK (Z-AAD-CMK) is a selective granzyme B inhibitor that blocks granzyme B protease activity, suitable for studies in inflammatory diseases and tumours.

Z-Ala-Ala-Asp-CMK

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Purity: 99.967%

Catalog No. T80745Alias Z-AAD-CMKCas No. 183284-21-1

Z-Ala-Ala-Asp-CMK (Z-AAD-CMK) is a selective granzyme B inhibitor that blocks granzyme B protease activity, suitable for studies in inflammatory diseases and tumours.

Pack Size	Price	Availability
1 mg	$123	In Stock
5 mg	$297	In Stock
10 mg	$496	In Stock
25 mg	$793	In Stock

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Purity:99.967%

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COA HPLC MS

Product Introduction

Bioactivity

Description	Z-Ala-Ala-Asp-CMK (Z-AAD-CMK) is a selective granzyme B inhibitor that blocks granzyme B protease activity, suitable for studies in inflammatory diseases and tumours.
In vitro	In the co-culture system of normal Homo sapiens keratinocytes and CD8⁺ T cells, treatment with 10 ng/mL Z-Ala-Ala-Asp-CMK for 72 hours can block granzyme B-mediated IL-18 activation and IFN-γ secretion [1]. In the model where OSC-3 cells were pre-treated with anticancer drugs or γ-rays before co-culture with LAK cells, treatment with 50 μM Z-Ala-Ala-Asp-CMK for 18 hours induced DNA fragmentation while suppressing Caspase-3 activity and ROS generation [2].
Synonyms	Z-AAD-CMK

Chemical Properties

Molecular Weight	441.86
Formula	C₁₉H₂₄ClN₃O₇
Cas No.	183284-21-1
Smiles	[C@@H](NC([C@@H](NC([C@@H](NC(OCC1=CC=CC=C1)=O)C)=O)C)=O)(C(CCl)=O)CC(O)=O
Color	White
Appearance	Solid
Sequence	Z-Ala-Ala-Asp-CMK
Sequence Short	Z-AAD-CMK

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (181.05 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2632 mL	11.3158 mL	22.6316 mL	113.1580 mL
5 mM	0.4526 mL	2.2632 mL	4.5263 mL	22.6316 mL
10 mM	0.2263 mL	1.1316 mL	2.2632 mL	11.3158 mL
20 mM	0.1132 mL	0.5658 mL	1.1316 mL	5.6579 mL
50 mM	0.0453 mL	0.2263 mL	0.4526 mL	2.2632 mL
100 mM	0.0226 mL	0.1132 mL	0.2263 mL	1.1316 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc