Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Hemopressin(rat) TFA, a nonapeptide originating from the α1-chain of hemoglobin, was first isolated from rat brain homogenates. It acts as an orally active, selective, and inverse agonist of the CB1 cannabinoid receptors and demonstrates antinociceptive effects in models of inflammatory pain [1] [2].
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Description | Hemopressin(rat) TFA, a nonapeptide originating from the α1-chain of hemoglobin, was first isolated from rat brain homogenates. It acts as an orally active, selective, and inverse agonist of the CB1 cannabinoid receptors and demonstrates antinociceptive effects in models of inflammatory pain [1] [2]. |
In vivo | Hemopressin(rat) TFA induces hypotension in anesthetized rats, undergoing metabolism by endopeptidase 24.15 (EP24.15), neurolysin (EP24.16), and angiotensin-converting enzyme (ACE) [1]. When administered orally, it mitigates mechanical hyperalgesia in CCI-rats for up to 6 hours. Additionally, treatment with Hemopressin(rat) TFA reduces Egr-1 immunoreactivity (Egr-1Ir) in the spinal cord's superficial dorsal horn of CCI rats [2]. |
Molecular Weight | 1202.28 |
Formula | C55H78F3N13O14 |
CAS No. | 1431329-47-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Hemopressin(rat) TFA 1431329-47-3 inhibitor inhibit