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Trans-caffeic acid

Name: Trans-caffeic acid
Brand: TargetMol
SKU: TMA0003
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TMA0003Cas No. 501-16-6

Alias 3,4-Dihydroxybenzeneacrylic acid

Trans-caffeic acid (3,4-Dihydroxybenzeneacrylic acid) can be used as a highly sensitive fluorescent probe for the detection of laccase in food and can also stimulate the growth of germ tissue.

Trans-caffeic acid

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Purity: 98.37%

Catalog No. TMA0003Alias 3,4-Dihydroxybenzeneacrylic acidCas No. 501-16-6

Trans-caffeic acid (3,4-Dihydroxybenzeneacrylic acid) can be used as a highly sensitive fluorescent probe for the detection of laccase in food and can also stimulate the growth of germ tissue.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$30	-	In Stock
50 mg	$37	-	In Stock
100 mg	$54	-	In Stock
500 mg	$128	-	In Stock
1 g	$189	-	In Stock
1 mL x 10 mM (in DMSO)	$59	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.37%

Appearance:Solid

Color:Yellow

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Trans-caffeic acid (3,4-Dihydroxybenzeneacrylic acid) can be used as a highly sensitive fluorescent probe for the detection of laccase in food and can also stimulate the growth of germ tissue.
In vitro	Trans-caffeic acid exhibited antiproliferative effects in human breast cancer cell lines MDA-MB-231 and MCF-7. After treatment with 5, 10, 25, 50, and 100 μM for 24, 48, and 72 hours, MTT assays showed time- and dose-dependent inhibition. At 50 μM for 48 hours, Trans-caffeic acid significantly induced cell cycle arrest and apoptosis, accompanied by elevated ROS levels and reduced mitochondrial membrane potential, suggesting involvement of oxidative stress and mitochondrial pathways[1].
In vivo	In BALB/c nude mice bearing MDA-MB-231 xenograft tumors, Trans-caffeic acid was administered intraperitoneally at 25 mg/kg once daily for 21 days. The treatment significantly reduced tumor volume compared to control without observable toxicity. Tumor tissues showed increased Bax and decreased Bcl-2 expression, indicating mitochondrial pathway–mediated apoptosis[1].
Synonyms	3,4-Dihydroxybenzeneacrylic acid

Chemical Properties

Molecular Weight	180.16
Formula	C₉H₈O₄
Cas No.	501-16-6
Smiles	C(=C/C(O)=O)\C1=CC(O)=C(O)C=C1
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (444.05 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.5506 mL	27.7531 mL	55.5062 mL	277.5311 mL
5 mM	1.1101 mL	5.5506 mL	11.1012 mL	55.5062 mL
10 mM	0.5551 mL	2.7753 mL	5.5506 mL	27.7531 mL
20 mM	0.2775 mL	1.3877 mL	2.7753 mL	13.8766 mL
50 mM	0.1110 mL	0.5551 mL	1.1101 mL	5.5506 mL
100 mM	0.0555 mL	0.2775 mL	0.5551 mL	2.7753 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc