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Maropitant citrate

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Catalog No. T35344 Copy Product Info
Purity: 98.91%
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Maropitant citrate is a synthetic neurokinin-1 receptor antagonist and substance P inhibitor, used for controlling vomiting in cats and dogs.
Maropitant citrate
Cas No. 359875-09-5
Other Forms of Maropitant citrate:
Pack SizePriceUSA StockGlobal StockQuantity
1 mg$53In StockIn Stock
5 mg$118In StockIn Stock
10 mg$173In StockIn Stock
25 mg$289In StockIn Stock
50 mg$429In StockIn Stock
100 mg$638In StockIn Stock
200 mg$889In StockIn Stock
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.
For research use only—not for human use. No sales to individuals. Use as intended only.
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Batch Information

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Purity:98.91%
Appearance:Solid
Color:White
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COA HPLC HNMR

Product Introduction

Bioactivity
Description
Maropitant citrate is a synthetic neurokinin-1 receptor antagonist and substance P inhibitor, used for controlling vomiting in cats and dogs.
Targets & IC50
NK1R:
In vitro
Maropitant citrate is a synthetic neurokinin-1 receptor antagonist. [1]
In vivo
Maropitant citrate 1 and 2 mg/kg were injected subcutaneously into Rhode Island red hens. Blood samples were collected within 36 hours after administration. The mean maximum plasma concentration, the time to reach the maximum concentration and the elimination half-life were 915.6 ng/ml and 1195.2 ng/ml, 0.49 h and 1.6 h, and 8.47 h and 8.58 h, respectively. [1] Treatment of ulcerative dermatitis (UD) mice with Maropitant citrate (1 mg/kg) significantly reduced the size of UD lesions in mice. [2]
Chemical Properties
Molecular Weight678.81
FormulaC38H50N2O9
Cas No.359875-09-5
SmilesC(CC(O)=O)(CC(O)=O)(C(O)=O)O.C([C@H]1[C@@H](NCC2=C(OC)C=CC(C(C)(C)C)=C2)C3CCN1CC3)(C4=CC=CC=C4)C5=CC=CC=C5.O
Storage & Solubility Information
StorageKeep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 µL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
µL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

NeurokininreceptorNeurokinin receptor
Related Tags: Maropitant citrate chemical structure | Maropitant citrate in vivo | Maropitant citrate in vitro | Maropitant citrate formula | Maropitant citrate molecular weight
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