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Aristolochic acid A
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Catalog No. T2801Cas No. 313-67-7
Alias TR 1736, Aristolochic Acid I, Aristolochic Acid
Aristolochic acid A is the main component of the plant extract aristolochic acids, primarily found in the herbaceous plants Aristolochia and Asarum. It significantly inhibits the activity of activator protein 1 (AP-1) and NF-κB, and downregulates the expression of the bladder cancer-associated BLCAP gene in human cells. It is commonly used to induce nephrotoxicity models.
Aristolochic acid A
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Purity: 99.97%
Catalog No. T2801Alias TR 1736, Aristolochic Acid I, Aristolochic AcidCas No. 313-67-7
Aristolochic acid A is the main component of the plant extract aristolochic acids, primarily found in the herbaceous plants Aristolochia and Asarum. It significantly inhibits the activity of activator protein 1 (AP-1) and NF-κB, and downregulates the expression of the bladder cancer-associated BLCAP gene in human cells. It is commonly used to induce nephrotoxicity models.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | $31 | In Stock | In Stock | |
| 25 mg | $52 | In Stock | In Stock | |
| 50 mg | $76 | - | In Stock | |
| 100 mg | $109 | - | In Stock | |
| 200 mg | $159 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $29 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.97%
Color:White to Yellow
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Product Introduction
Aristolochic acid A AI Summary
Aristolochic acid A exhibits a diverse range of bioactivities. It has demonstrated growth inhibitory activity against a human cancer cell line in the NCI's anticancer drug screening program with a GI50 value of 883.0 nM and shows significant cytotoxicity in HEK293 cells with an EC50 value of 118340.0 nM. It also exhibits antispasmodic activity in guinea pig ileum by inhibiting electrically-induced smooth muscle contraction by 64.0% and acetylcholine-induced contraction by more than 100.0%. As an inhibitor of CDK2, it has an IC50 value greater than 20,000.0 nM, indicating low potency. The compound exhibits various inhibitory effects on enzymatic and molecular interactions, such as those related to MLL-related leukemias, tau fibril formation, Cytochrome P450 3A4, and several others. It enhances SMN2 splice variant expression, activates Nrf2, and shows inhibitory effects on ALDH1A1, uPA generation, Vif-A3F interactions, Glutaminase (GLS), Hepatitis C Virus (HCV), Pin1, TDP1, and PTHR. In addition, Aristolochic acid A exhibits anti-inflammatory activity in human neutrophils by inhibiting fMLP/CB-induced superoxide anion generation and elastase release with IC50 values greater than 10.0 ug/mL. It inhibits sodium fluorescein uptake in OATP1B3- and OATP1B1-transfected CHO cells at a concentration of 10 uM, with 107.62% and 76.91% inhibition respectively. Lastly, it shows mild antibacterial activity against Escherichia coli and Pseudomonas aeruginosa, and significant antifungal activity against Candida albicans, but lacks efficacy against several other bacterial and fungal strains..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Aristolochic acid A is the main component of the plant extract aristolochic acids, primarily found in the herbaceous plants Aristolochia and Asarum. It significantly inhibits the activity of activator protein 1 (AP-1) and NF-κB, and downregulates the expression of the bladder cancer-associated BLCAP gene in human cells. It is commonly used to induce nephrotoxicity models. |
| Synonyms | TR 1736, Aristolochic Acid I, Aristolochic Acid |
| Molecular Weight | 341.27 |
| Formula | C17H11NO7 |
| Cas No. | 313-67-7 |
| Smiles | COc1cccc2c1cc([N+]([O-])=O)c1c(cc3OCOc3c21)C(O)=O |
| Relative Density. | 1.571g/cm3 |
| Storage | keep away from direct sunlight,store under nitrogen,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 9.13 mg/mL (26.75 mM), Sonication is recommended.  | |||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (2.93 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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