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Pomalidomide-amino-PEG3-NH2 hydrochloride

🥰Excellent
Catalog No. T39953Cas No. 2380273-75-4

Pomalidomide-amino-PEG3-NH2 hydrochloride is an E3 ligase ligand-linker conjugate containing a pomalidomide-based cereblon ligand and a linker, which can be used to synthesize PROTACs.

Pomalidomide-amino-PEG3-NH2 hydrochloride
Other Forms of Pomalidomide-amino-PEG3-NH2 hydrochloride:
Pomalidomide-amino-PEG3-NH2T399522380273-74-3
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Pomalidomide-amino-PEG3-NH2 hydrochloride

🥰Excellent
Purity: 98.87%
Catalog No. T39953Cas No. 2380273-75-4
Pomalidomide-amino-PEG3-NH2 hydrochloride is an E3 ligase ligand-linker conjugate containing a pomalidomide-based cereblon ligand and a linker, which can be used to synthesize PROTACs.
Pack SizePriceAvailabilityQuantity
1 mg$40In Stock
5 mg$90In Stock
10 mg$132In Stock
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Batch Information

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Purity:98.87%
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COA HNMR HPLC

Product Introduction

Bioactivity
Description
Pomalidomide-amino-PEG3-NH2 hydrochloride is an E3 ligase ligand-linker conjugate containing a pomalidomide-based cereblon ligand and a linker, which can be used to synthesize PROTACs.
In vitro
PROTACs consist of two distinct ligands linked by a linker: one ligand binds to the E3 ubiquitin ligase, and the other ligand binds to the target protein. PROTACs utilize the intracellular ubiquitin-proteasome system to achieve selective degradation of the target protein. [2]
Chemical Properties
Molecular Weight498.91
FormulaC21H27ClN4O8
Cas No.2380273-75-4
SmilesCl.O=C(NC1=CC=CC=2C(=O)N(C(=O)C12)C3C(=O)NC(=O)CC3)COCCOCCOCCN
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 80 mg/mL (160.35 mM.), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.0044 mL10.0218 mL20.0437 mL100.2185 mL
5 mM0.4009 mL2.0044 mL4.0087 mL20.0437 mL
10 mM0.2004 mL1.0022 mL2.0044 mL10.0218 mL
20 mM0.1002 mL0.5011 mL1.0022 mL5.0109 mL
50 mM0.0401 mL0.2004 mL0.4009 mL2.0044 mL
100 mM0.0200 mL0.1002 mL0.2004 mL1.0022 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Pomalidomide-amino-PEG-3-NH2 hydrochloridePomalidomideaminoPEG3NH2 hydrochloridePomalidomide amino PEG3 NH2 hydrochlorideLigandforE3LigaseLigand for E3 LigaseE3 Ligase
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